Name | 4'-Chloroacetanilide |
Synonyms | 4-CHLORACETANILIDE p-Chloroacetanilide 4-Chloroacetanilide P-CHLOROACETANILIDE 4-CHLOROACETANILIDE 4'-CHLOROACETANILIDE 4'-Chloroacetanilide ACETAMINOPHENE IMP J LABOTEST-BB LT00792311 ACETAMINOPHEN IMPURITY J ACETIC ACID 4-CHLOROANILIDE N-(4-Chlorophenyl)acetamide 2-(4-chlorophenyl)acetamide |
CAS | 539-03-7 |
EINECS | 208-707-8 |
InChI | InChI=1/C8H8ClNO/c1-6(11)10-8-4-2-7(9)3-5-8/h2-5H,1H3,(H,10,11) |
Molecular Formula | C8H8ClNO |
Molar Mass | 169.61 |
Density | 1,385 g/cm3 |
Melting Point | 176-178°C(lit.) |
Boling Point | 333 °C |
Flash Point | 333°C |
Water Solubility | Insoluble in water. |
Solubility | Actually insoluble in water, soluble in ethanol, ether and carbon disulfide; slightly soluble in CCl4 and benzene. |
Vapor Presure | 0.000123mmHg at 25°C |
Appearance | White to light brown powder |
Color | White or grayish-beige |
Merck | 14,2111 |
BRN | 509638 |
pKa | 14.25±0.70(Predicted) |
Storage Condition | 2-8°C |
Sensitive | Keep away from kindling and heat source. Protect from direct sunlight |
Refractive Index | 1.5670 (estimate) |
MDL | MFCD00000612 |
Use | For organic synthesis and dye intermediates |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
RTECS | AE1001000 |
TSCA | Yes |
HS Code | 29242990 |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
Overview | The organic amide compound p-chloroacetanilide is an important intermediate in organic synthesis. They are widely used in pharmaceutical structural substances, polymer intermediates, photoelectric materials, flame retardancy, pesticide preparation, etc. |
preparation | preparation of p-chloroacetanilide: 113.5mg(0.5mmol) of 4-chlorophenyl diazotetrafluoroborate, 0.1mmol of cuprous iodide, 0.5mmol of potassium phosphate and 1.0mmol of water are added into a Schlenk tube under nitrogen environment, 1mL of acetonitrile is added under air condition, and the reaction is stirred at 80oC for 12 hours. the yield of the reaction is 68%. |
Use | Used as an intermediate in organic synthesis and dyes |
category | pesticide |
toxicity classification | poisoning |
acute toxicity | abdominal cavity-rat LD50: 350 mg/kg; Abdominal cavity-mouse LD50: 730 mg/kg |
flammability hazard characteristics | thermal decomposition discharges toxic nitrogen oxides and chloride smoke |
storage and transportation characteristics | warehouse low temperature ventilation and drying |
fire extinguishing agent | water, carbon dioxide, foam, dry powder |
toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |