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4-Fluorobenzaldehyde

4-Fluorobenzaldehyde

CAS: 459-57-4

Molecular Formula: C7H5FO

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4-Fluorobenzaldehyde - Names and Identifiers

Name 4-Fluorobenzaldehyde
Synonyms PFBA
PFAD
JACS-459-57-4
Fluorobenzaldehyde4
p-Fluorobenzaldehyde
4-fluoro-benzaldehyd
4-Fluorobenzaldehyde
P-FLUOROBENZALDEHYDE
4-fluoro-Benzaldehyde
Paroxetine Impurity 58
Benzaldehyde, p-fluoro
Para-Fluorobenzaldehyde
Benzaldehyde, p-fluoro-
1-fluoro-4-methoxybenzene
Fluorobenzaldehyde colorless liq
4-Fluorobenzaldehyde, p-Fluorobenzaldehyde, Benzaldehyde 4-fluoro-, 4-fluoro-benzaldehyde
CAS 459-57-4
EINECS 207-293-6
InChI InChI=1/C7H7FO/c1-9-7-4-2-6(8)3-5-7/h2-5H,1H3
InChIKey UOQXIWFBQSVDPP-UHFFFAOYSA-N

4-Fluorobenzaldehyde - Physico-chemical Properties

Molecular FormulaC7H5FO
Molar Mass124.11
Density1.157 g/mL at 25 °C (lit.)
Melting Point-10 °C (lit.)
Boling Point181 °C/758 mmHg (lit.)
Flash Point134°F
Water SolubilityIMMISCIBLE
Solubility Chloroform, Methanol
Vapor Presure19 hPa (70 °C)
AppearanceLiquid
Specific Gravity1.157
ColorClear colorless to yellow
BRN385857
Storage ConditionStore below +30°C.
StabilityAir Sensitive
SensitiveAir Sensitive
Refractive Indexn20/D 1.521(lit.)
Physical and Chemical PropertiesDensity 1.157
melting point -10°C
boiling point 181 ° C (758 mmHg)
refractive index 1.5195-1.5215
flash point 56°C
water-soluble IMMISCIBLE
UseUsed as pesticide, pharmaceutical intermediates

4-Fluorobenzaldehyde - Risk and Safety

Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S37/39 - Wear suitable gloves and eye/face protection
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S27 - Take off immediately all contaminated clothing.
UN IDsUN 1989 3/PG 3
WGK Germany2
FLUKA BRAND F CODES9-23
TSCAT
HS Code29130000
Hazard NoteFlammable
Hazard Class3.2
Packing GroupIII

4-Fluorobenzaldehyde - Reference Information

NIST chemical information Information provided by: webbook.nist.gov (external link)
EPA chemical information Information provided by: ofmpub.epa.gov (external link)
application p-fluorobenzaldehyde (4-fluorobenzaldehyde) is a very important fine chemical, which has important uses in medicine, pesticides, new materials, polymers, etc. For example, in medicine, important drugs such as flupenol, floperide, rosuvastatin calcium, etc., among which it is used to make rosuvastatin calcium core The key raw material has very important value.
preparation method (1) add 110.5g of p-fluorotoluene to 500ml of medium, continuously introduce chlorine into the medium, carry out chlorination reaction, control the reaction progress by GC tracking method, make the content of benzyl monochloride product less than 2%, and the content of benzyl trichloride product less than 10%, (2) add 6.9g of FeCl3 ZnCl2 catalyst, then raise the temperature to 130 ℃, add 1.7ml of water to initiate the reaction for hydrolysis, control the temperature to reflux at 130 ℃, (3) add water drop by drop to the three-mouth flask to completely hydrolyze the benzyl dichloride product, (4) After the reaction is over, adjust the pH value to 8.0~9.0 with a 30% concentration of sodium hydroxide solution, and then let it stand and layer, (5) Add hydrochloric acid with a concentration of 10%, adjust the pH value to 5.0~7.0, add the toluene extraction organic layer, (6) finally spin the solvent, dry the product, and rectify the organic layer to obtain p-fluorobenzaldehyde. The yield of p-fluorobenzaldehyde was 80%.
use p-fluorobenzaldehyde is an intermediate for the preparation of 3-phenoxy -4-fluorobenzaldehyde, which can prepare pyrethroids such as cyhalothrin and fluorothrin.
Used as an intermediate for pesticides and medicines
It is an important intermediate for medicines, dyes and pesticides. In medicine, it is used to manufacture chlorobeterbutyl aluminum salt, chlorobeterbutyl, p-fluorophenoxy isobutyric acid, etc.; in dyes, it is used to prepare weakly acidic light yellow 2G and weakly acidic light yellow 5G, and also used to prepare rice JFF, plant growth regulators, etc.
Production method The preparation method is to use p-chlorotoluene as raw material, first fluorinated with potassium fluoride to produce p-fluorotoluene, and then through methyl Chlorination makes it produce 4-fluorobenzene dichloride, and then hydrolyze to obtain p-fluorobenzaldehyde. Or by fluorinating p-chlorobenzaldehyde with potassium fluoride, p-fluorobenzaldehyde is directly obtained.
Last Update：2024-04-09 20:52:54
4-Fluorobenzaldehyde
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CAS: 459-57-4
Tel: 15335994747
Email: 3521670276@qq.com
Mobile: 15335994747
QQ: 3521670276 Click to send a QQ message
Wechat: A2020071098
Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: 4-Fluorobenzaldehyde Request for quotation
CAS: 459-57-4
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Jiangsu Pules Biotechnology Co.,Ltd.
Multiple Specifications
Product Name: 4-Fluorobenzaldehyde Request for quotation
CAS: 459-57-4
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Guangzhou Yuanda New Material Co.,Ltd
Product Name: 4-Fluorobenzaldehyde Request for quotation
CAS: 459-57-4
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589 Click to send a QQ message
Wechat: +86 19849939632
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: 4-Fluorobenzaldehyde Request for quotation
CAS: 459-57-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: p-Fluoro benzaldehyde Visit Supplier Webpage Request for quotation
CAS: 459-57-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
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4-Fluorobenzaldehyde
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