4-HYDROXY-2-THIOPYRIMIDINE
2-Thiouracil
CAS: 141-90-2
Molecular Formula: C4H4N2OS
4-HYDROXY-2-THIOPYRIMIDINE - Names and Identifiers
| Name | 2-Thiouracil |
| Synonyms | 2-TU 2-thio-uraci 2-Thiouracil 2-ThiouraCll 2-MERCAPTO-4-PYRIMIDONE 4-HYDROXY-2-THIOPYRIMIDINE 4-HYDROXY-2-MERCAPTOPYRIMIDINE 2-MERCAPTO-4-HYDROXYPYRIMIDINE 2,3-dihydro-2-thioxo-4(1h)-pyrimidino |
| CAS | 141-90-2 |
| EINECS | 205-508-8 |
| InChI | InChI=1/C4H4N2OS/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) |
| InChIKey | ZEMGGZBWXRYJHK-UHFFFAOYSA-N |
4-HYDROXY-2-THIOPYRIMIDINE - Physico-chemical Properties
| Molecular Formula | C4H4N2OS |
| Molar Mass | 128.15 |
| Density | 1.368 (estimate) |
| Melting Point | >300 °C (lit.) |
| Boling Point | 337.2°C at 760 mmHg |
| Flash Point | 157.7°C |
| Water Solubility | 0.5 g/L |
| Solubility | Solubility in water: 0.5g/L, soluble in lye. |
| Vapor Presure | 5.45E-05mmHg at 25°C |
| Appearance | White or light yellow soft crystal or crystalline powder |
| Color | White to cream |
| Maximum wavelength(λmax) | ['271nm(H2O)(lit.)'] |
| Merck | 14,9366 |
| BRN | 112227 |
| pKa | pKa 7.46 (Uncertain) |
| Storage Condition | Store below +30°C. |
| Refractive Index | 1.7000 (estimate) |
| MDL | MFCD00006039 |
| Use | Used as a pharmaceutical Intermediate |
| In vitro study | 2-Thiouracil is an established antithyroid drug and a research reagent widely used for early detection, targeting metastatic melanoma. In addition, 2-Thiouracil is also a selective neuronal nitric oxide synthase inhibitor, antagonizing Tetrahydrobiopterin-dependent enzyme activation and dimerization. |
4-HYDROXY-2-THIOPYRIMIDINE - Risk and Safety
| Risk Codes | R40 - Limited evidence of a carcinogenic effect R45 - May cause cancer R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S53 - Avoid exposure - obtain special instructions before use. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 3 |
| RTECS | YR1575000 |
| TSCA | Yes |
| HS Code | 29335995 |
4-HYDROXY-2-THIOPYRIMIDINE - Upstream Downstream Industry
| Raw Materials | Sodium methoxide Thiourea |
4-HYDROXY-2-THIOPYRIMIDINE - Introduction
Solubility in water: 0.5g/L, soluble in lye.
Last Update：2022-10-16 17:13:53
4-HYDROXY-2-THIOPYRIMIDINE - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| (IARC) carcinogen classification | 2B (Vol. Sup 7,79) 2001 |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| traits | 2-thiouracil is white-like or white powder. |
| use | 2-thiouracil can be used as a pharmaceutical intermediate and electroplating industry. Used as a pharmaceutical intermediate |
| Biological activity | 2-Thiouracil is a sulfhydryl uracil derivative, an anti-hyperthyroidism drug. |
| target | Ki: 20 μM (nNOS) |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:06
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Raw Materials for 4-HYDROXY-2-THIOPYRIMIDINE