4-HYDROXY-3-BROMOPYRIDINE
3-Bromo-4-hydroxypyridine
CAS: 36953-41-0
Molecular Formula: C5H4BrNO
4-HYDROXY-3-BROMOPYRIDINE - Names and Identifiers
| Name | 3-Bromo-4-hydroxypyridine |
| Synonyms | 3-Bromopyridin-4-ol 3-Bromo-4-pyridinol 3-BROMO-4-PYRIDINOL 4-Pyridinol, 3-bromo- 3-bromopyridin-4(1H)-one 4-HYDROXY-3-BROMOPYRIDINE 3-Bromo-4-hydroxypyridine 3-BROMO-4-HYDROXYPYRIDINE Synthesis of 3-bromopyridin-4-ol |
| CAS | 36953-41-0 |
| InChI | InChI=1/C5H4BrNO/c6-4-3-7-2-1-5(4)8/h1-3H,(H,7,8) |
4-HYDROXY-3-BROMOPYRIDINE - Physico-chemical Properties
| Molecular Formula | C5H4BrNO |
| Molar Mass | 174 |
| Density | 1.788±0.06 g/cm3(Predicted) |
| Melting Point | 225-230℃ |
| Boling Point | 338.2±22.0 °C(Predicted) |
| Flash Point | 101.6°C |
| Vapor Presure | 0.0306mmHg at 25°C |
| pKa | 3.71±0.18(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.6 |
| MDL | MFCD01646107 |
4-HYDROXY-3-BROMOPYRIDINE - Introduction
3-Bromo-4-hydroxypyridine is an organic compound with a chemical formula of C5H4BrNO and a molecular weight of 156.99g/mol. It is a white to pale yellow solid with a peculiar bitter taste. The following is a description of some basic properties, uses, preparation and safety information about 3-Bromo-4-hydroxypyridine:
Nature:
1. Appearance: White to light yellow solid.
2. melting point: 101-104 ℃.
3. thermal stability: stable at room temperature, but may decompose at high temperature.
4. Solubility: Soluble in water, alcohols and some organic solvents, such as ethanol, dichloromethane and dimethylformamide.
Use:
1. As an intermediate in organic synthesis, it is widely used in the fields of medicine and pesticide.
2. in organic synthesis, the structural unit of 3-Bromo-4-hydroxypyridine can be introduced by intermolecular or intramolecular reactions, such as substitution reactions, addition reactions, etc.
3.3-Bromo-4-hydroxypyridine can also be used to synthesize other compounds, such as pyridine dyes and complexes, which have a wide range of applications in scientific research, industrial production and medical fields.
Preparation Method:
There are many preparation methods for 3-Bromo-4-hydroxypyridine. The common methods include the following steps:
1. An electrophilic substitution reaction is carried out using an alkali catalyst such as sodium hydroxide under the conditions of 3-bromopyridine to substitute a hydrogen atom with a hydroxyl group.
2. The product is extracted with an appropriate extraction agent (such as dichloromethane), and the pure product of 3-Bromo-4-hydroxypyridine is obtained by concentration and crystallization.
Safety Information:
1. 3-Bromo-4-hydroxypyridine is irritating to eyes and skin. Please avoid contact. If it comes into contact with skin or eyes, rinse with plenty of water immediately and seek medical assistance.
2. avoid inhalation or ingestion of the substance, such as inadvertent inhalation or ingestion, should promptly seek medical attention.
3. in operation, should use appropriate protective measures, such as wearing gloves, respiratory protection and safety glasses.
4. When stored, it should be sealed and kept away from fire and oxidant, and avoid contact with oxygen to avoid fire or explosion.
Please note that the above information provides a general description. In actual application, judgment and operation should be made according to the specific situation, and relevant regulations and safety operation procedures should be observed.
Nature:
1. Appearance: White to light yellow solid.
2. melting point: 101-104 ℃.
3. thermal stability: stable at room temperature, but may decompose at high temperature.
4. Solubility: Soluble in water, alcohols and some organic solvents, such as ethanol, dichloromethane and dimethylformamide.
Use:
1. As an intermediate in organic synthesis, it is widely used in the fields of medicine and pesticide.
2. in organic synthesis, the structural unit of 3-Bromo-4-hydroxypyridine can be introduced by intermolecular or intramolecular reactions, such as substitution reactions, addition reactions, etc.
3.3-Bromo-4-hydroxypyridine can also be used to synthesize other compounds, such as pyridine dyes and complexes, which have a wide range of applications in scientific research, industrial production and medical fields.
Preparation Method:
There are many preparation methods for 3-Bromo-4-hydroxypyridine. The common methods include the following steps:
1. An electrophilic substitution reaction is carried out using an alkali catalyst such as sodium hydroxide under the conditions of 3-bromopyridine to substitute a hydrogen atom with a hydroxyl group.
2. The product is extracted with an appropriate extraction agent (such as dichloromethane), and the pure product of 3-Bromo-4-hydroxypyridine is obtained by concentration and crystallization.
Safety Information:
1. 3-Bromo-4-hydroxypyridine is irritating to eyes and skin. Please avoid contact. If it comes into contact with skin or eyes, rinse with plenty of water immediately and seek medical assistance.
2. avoid inhalation or ingestion of the substance, such as inadvertent inhalation or ingestion, should promptly seek medical attention.
3. in operation, should use appropriate protective measures, such as wearing gloves, respiratory protection and safety glasses.
4. When stored, it should be sealed and kept away from fire and oxidant, and avoid contact with oxygen to avoid fire or explosion.
Please note that the above information provides a general description. In actual application, judgment and operation should be made according to the specific situation, and relevant regulations and safety operation procedures should be observed.
Last Update：2024-04-09 15:17:57
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CAS: 36953-41-0
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CAS: 36953-41-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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