4-HYDROXYBENZONITRILE
4-Cyanophenol
CAS: 767-00-0
Molecular Formula: C7H5NO
4-HYDROXYBENZONITRILE - Names and Identifiers
| Name | 4-Cyanophenol |
| Synonyms | AKOS 217-25 AKOS B004225 P-CYANOPHENOL 4-CYANOPHENOL 4-Cyanophenol CYANOPHENOL(4-) 4-cyanophenolate 4-HYDROXYBENZONITRILE p-Hydroxybenzonitrile 4-Hydroxybenzonitrile 4-HYDROXYBENZONITRILE FOR SYNTHESIS |
| CAS | 767-00-0 |
| EINECS | 212-175-2 |
| InChI | InChI=1/C7H5NO/c8-5-6-1-3-7(9)4-2-6/h1-4,9H/p-1 |
4-HYDROXYBENZONITRILE - Physico-chemical Properties
| Molecular Formula | C7H5NO |
| Molar Mass | 119.12 |
| Density | 1.1871 (rough estimate) |
| Melting Point | 110-113°C(lit.) |
| Boling Point | 146 °C / 2mmHg |
| Flash Point | 123.882°C |
| Water Solubility | slightly soluble |
| Solubility | Slightly soluble in water; soluble in methanol, acetone, ether, chloroform and other organic solvents. |
| Vapor Presure | 0.002mmHg at 25°C |
| Appearance | White crystal |
| Color | Off-white to beige-gray |
| BRN | 386130 |
| pKa | 7.97(at 25℃) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.5800 (estimate) |
| MDL | MFCD00002312 |
| Physical and Chemical Properties | trait scale-like white crystals. |
| Use | For the production of liquid crystals, pharmaceuticals, dyes, pesticides, etc |
4-HYDROXYBENZONITRILE - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | DI4375000 |
| TSCA | Yes |
| HS Code | 29269095 |
| Hazard Note | Irritant |
4-HYDROXYBENZONITRILE - Nature
Open Data Verified Data
colorless plate-like crystal, melting point 113 °c.
Last Update：2024-01-02 23:10:35
4-HYDROXYBENZONITRILE - Preparation Method
Open Data Verified Data
- p-Hydroxybenzoic acid method from p-Hydroxybenzoic acid amination.
- The p-cresol method is obtained by ammoxidation of p-cresol.
- p-hydroxybenzaldehyde method from p-hydroxybenzaldehyde and hydroxylamine hydrochloride reaction.
Last Update：2022-01-01 10:54:51
4-HYDROXYBENZONITRILE - Introduction
Slightly soluble in water; soluble in methanol, acetone, ether, chloroform and other organic solvents.
Last Update：2022-10-16 17:28:31
4-HYDROXYBENZONITRILE - Use
Open Data Verified Data
This product is used for the synthesis of liquid crystal materials, pesticides, spices, corrosion inhibitors, etc.
Last Update：2022-01-01 10:54:51
4-HYDROXYBENZONITRILE - Safety
Open Data Verified Data
25kg/paper drum (lined with plastic bag),20kg/woven bag (lined with plastic bag).
Last Update：2022-01-01 10:54:51
4-HYDROXYBENZONITRILE - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | p-hydroxybenzonitrile, namely P-cyanophenol, is an intermediate of the herbicide bromophenonitrile and the insecticide borer nitrile and benzonitrile phosphorus. The intermediate is synthesized by machine, which is used for the production of pesticide fenafinil and benzonitrile phosphorus. used in the production of liquid crystals, pharmaceuticals, dyes, pesticide intermediates, etc. is an important fine chemical raw materials and intermediates, widely used in the synthesis of a variety of medicines, spices, pesticides, liquid crystal material and corrosion inhibitor, etc. p-cyanophenol, also known as P-hydroxybenzonitrile (p-hydroxybenzonitrile), is an intermediate of organophosphorus insecticide borer nitrile and benzonitrile phosphorus, is an intermediate of herbicide bromophenonitrile, and is also a liquid crystal material, intermediates of spices, etc. liquid crystal materials, pesticides, spices, etc. can be synthesized used in the production of liquid crystals, pharmaceuticals, dyes, pesticides, etc. pharmaceutical intermediates; Liquid crystal material intermediates, perfume intermediates. p-hydroxybenzonitrile is an extremely important raw material and intermediate in fine organic chemical industry. Widely used in the synthesis of a variety of medicines, spices, pesticides, liquid crystal materials and corrosion inhibitors. |
| production method | There are a variety of preparation methods, including P-hydroxybenzoate amination method, P-cresol ammonia oxidation method, P-hydroxybenzaldehyde method, etc, the method of p-Hydroxybenzoic acid was used in domestic production. The p-Hydroxybenzoic acid, urea and phosphorus pentoxide were added into a stainless steel reactor, stirred and mixed, heated and melted, and then heated to above 200 ℃ under reduced pressure for dehydration to obtain p-cyanophenol with a yield of 84%. derived from the interaction of p-carboxybenzoic acid with urea in the presence of phosphorus pentasulfide. The p-Hydroxybenzoic acid, urea and phosphorus pentasulfide were added into a stainless steel reactor, stirred and mixed, heated and melted, and dehydrated under reduced pressure at 200 ° C. Or higher. The preparation method is to put P-hydroxybenzaldehyde, hydroxylamine hydrochloride and acetic acid in the reaction kettle, heated and stirred for 1H, desolventilate and recover part of the acetic acid, cool and pour into water, neutralize with sodium hydroxide solution, filter, the product was washed with water. It is also possible to add P-Hydroxybenzoic acid, urea and phosphorus pentasulfide into a stainless steel reactor for stirring and mixing, heat and melt, and heat to above 200 ° C. Under reduced pressure to obtain a product by dehydration. |
Last Update：2024-04-09 20:52:54
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