4-Hydroxy-5-iodopyriMidine
5-iodopyrimidin-4(3H)-one
CAS: 4349-07-9
Molecular Formula: C4H3IN2O
4-Hydroxy-5-iodopyriMidine - Names and Identifiers
4-Hydroxy-5-iodopyriMidine - Physico-chemical Properties
| Molecular Formula | C4H3IN2O |
| Molar Mass | 221.98 |
| Density | 2.40±0.1 g/cm3(Predicted) |
| Melting Point | 254-265℃ |
| Boling Point | 229.2°C at 760 mmHg |
| Flash Point | 92.4°C |
| Water Solubility | Soluble in water (67 g/L) (25°C). |
| Vapor Presure | 0.0468mmHg at 25°C |
| Appearance | Solid |
| pKa | 7.48±0.40(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| Sensitive | Light Sensitive |
| Refractive Index | 1.761 |
4-Hydroxy-5-iodopyriMidine - Reference Information
| introduction | 4-hydroxy -5-iodopyrimidine is also called 5-iodopyrimidine -4(3H)-ketone, which can be used as an intermediate in organic synthesis. 4-Hydroxy-5-iodopyrimidine can be prepared by reacting with iodine under the action of sodium hydroxide from pyrimidine -4(3H)-ketone as the reaction material, and can also be prepared by reacting with N-iodosuccinimide. |
| preparation | 10g pyrimidine -4(3H)-ketone is dissolved in 156mL acetic acid, and 25.8gN-iodosuccinimide is added to it at 70 ℃, and heated to 100 ℃., Then stir for 30 minutes. After the reaction is complete, the mixture is cooled to room temperature, then cooled in ice to cause crystallization of the product, and then filtered under reduced pressure. The solids thus obtained were washed with water and dried under reduced pressure to obtain the title compound 4-hydroxy-5-iodopyrimidine with yield (16g,67%). |
Last Update：2024-04-09 21:00:56
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