4-Iodo-3-nitrobenzamide
4-Iodo-3-nitrobenzamide
CAS: 160003-66-7
Molecular Formula: C7H5IN2O3
4-Iodo-3-nitrobenzamide - Names and Identifiers
| Name | 4-Iodo-3-nitrobenzamide |
| Synonyms | NIBA CS-420 INO2BA 109775 BSI201 BSI-201 INIPARIB Iniparib BSI 201 IND-71677 IND-71677 NSC-746045 AntiPARP-2 NSC-746045 4-iodo-3-nitrobenzamide 4-Iodo-3-nitrobenzamide |
| CAS | 160003-66-7 |
| EINECS | 685-396-9 |
| InChI | InChI=1/C7H5IN2O3/c8-5-2-1-4(7(9)11)3-6(5)10(12)13/h1-3H,(H2,9,11) |
4-Iodo-3-nitrobenzamide - Physico-chemical Properties
| Molecular Formula | C7H5IN2O3 |
| Molar Mass | 292.03 |
| Density | 2.055±0.06 g/cm3(Predicted) |
| Boling Point | 344.8±32.0 °C(Predicted) |
| Flash Point | 162.302°C |
| Solubility | DMSO ≥56mg/mL Water <1.2mg/mL Ethanol ≥35mg/mL |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | powder |
| Color | white to beige |
| pKa | 14?+-.0.50(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Refractive Index | 1.696 |
| Use | Iniparib (BSI-201) is an antineoplastic originally thought to be a poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor. Recent studies indicate Iniparib is not a PARP-1 inhibitor, and its mechanism of action is currently unknown. |
| In vitro study | BSI-201 was originally thought to be a prodrug of 4-iodo-3-nitrosobenzamide, an agent that covalently inhibits PARP1 by binding to the first zinc finger structure of PARP1. Treatment of 855-2 cells with 120 μm BSI-201 and buthionine sulfoximine (BSO) induced cell death by 95%, which was similar to that of other human tumor cells. BSI-201 inhibits the growth of E-ras 20 cells, while the addition of BOS in combination enhances the effect by 20 times. Recent studies have shown that BSI-201 cannot inhibit PARP enzyme activity, but can non-selectively alter cysteine-containing proteins in tumor cells, indicating that the mechanism of BSI-201 action is not through inhibition of PARP activity. 100 μm BSI-201 inhibits ionizing radiation-induced single-strand break (SSBs) repair by 55% in 2 hours, while PARP1 inhibition reverses repair, explain that the suppression mechanism does not involve capturing PARP. BSI-201 does not selectively kill homologous recombination between BRCA2-deficient PEO1 and BRCA2-revertant PEO4, or ATM-deficient GM16666 and ATM-restored GM16667 fibroblasts (HR)-Defective cells. Although cells can be moderately sensitized to Etoposide, BSI-201 SKOV3 cells cannot be sensitized to topoisomerase I inhibitors, Cisplatin, Gemcitabine, or Paclitaxel, alternatively, concentrations up to 100 μm did not inhibit pADPr formation. In contrast, multiple cell lines were toxic at BSI-201 concentrations above 40 μm, indicating that this mechanism is independent of PARP. |
4-Iodo-3-nitrobenzamide - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes R43 - May cause sensitization by skin contact |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
4-Iodo-3-nitrobenzamide - Introduction
Iniparib (BSI-201) is a PARP1 inhibitor that is effective against triple negative breast cancer (TNBC).
Last Update：2022-10-16 17:14:13
4-Iodo-3-nitrobenzamide - Reference Information
| biological activity | Iniparib (BSI-201, NSC-746045, IND-71677) is a PARP1 inhibitor that has a role in triple negative breast cancer (TNBC). Phase 3. |
| Target | Value |
Last Update：2024-04-09 19:05:10
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CAS: 160003-66-7
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CAS: 160003-66-7
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Mobile: 18021002903
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