4-METHYL-2-SULFANILAMIDO-PYRIMIDINE
sulfamerazine free acid
CAS: 127-79-7
Molecular Formula: C11H12N4O2S
4-METHYL-2-SULFANILAMIDO-PYRIMIDINE - Names and Identifiers
| Name | sulfamerazine free acid |
| Synonyms | DEBENAL METSULFA Sulfamerazine METHYLPYRIMAL Sulfamerazine solution LABOTEST-BB LT00455132 sulfamerazine free acid SULFAMERAZINE PH FR-FU-USP 2-SULFANILAMIDO-4-METHYLPYRIMIDINE 2-Sulphanilamido-4-methylpyrimidine 4-METHYL-2-SULFANILAMIDO-PYRIMIDINE N1-(4-methylpyrimidin-2-yl)sulphanilamide 4-amino-N-(4-methylpyrimidin-2-yl)benzenesulfonamide 4-AMINO-N-[4-METHYL-2-PYRIMIDINYL]-BENZENESULFONAMIDE 4-AMINO-N-(4-METHYL-PYRIMIDIN-2-YL)-BENZENESULFONAMIDE |
| CAS | 127-79-7 |
| EINECS | 204-866-2 |
| InChI | InChI=1/C11H12N4O2S/c1-8-6-7-13-11(14-8)15-18(16,17)10-4-2-9(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15) |
4-METHYL-2-SULFANILAMIDO-PYRIMIDINE - Physico-chemical Properties
| Molecular Formula | C11H12N4O2S |
| Molar Mass | 264.3 |
| Density | 1.3364 (rough estimate) |
| Melting Point | 234-238°C |
| Boling Point | 519.1±52.0 °C(Predicted) |
| Flash Point | 267.8°C |
| Water Solubility | 202mg/L(20 ºC) |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 7.03E-11mmHg at 25°C |
| Appearance | neat |
| Color | White to Off-White |
| Merck | 14,8913 |
| BRN | 249133 |
| pKa | pKa 2.29(H2Ot = 24.0I = 0.5 (NaCl)) (Uncertain) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.6440 (estimate) |
| Use | Used as a pharmaceutical Intermediate |
| In vitro study | Sulfamerazine exhibits a double exponential decay in water and a triple exponential decay in cyclodextrin solutions. Sulfamerazine exhibits a significant high-field shift in the complex, indicating that the aniline ring is deeply enclosed in the CD cavity. |
| In vivo study | Sulfamerazine caused a significant change in the shape of the concentration-time curve as a function of age, which strongly explained the defective absorption rate in lambs after the first week of birth. Sulfamerazine had a significant beneficial effect on the lifespan of rats, significantly increasing the number of female hamsters, and the rats fed Sulfamerazine reached a higher maximum body weight than the control group. |
4-METHYL-2-SULFANILAMIDO-PYRIMIDINE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 2 |
| RTECS | WP0750000 |
| FLUKA BRAND F CODES | 10 |
| TSCA | Yes |
| HS Code | 2935904000 |
| Toxicity | LD50 oral in mouse: 25gm/kg |
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