4-MORPHOLINO-PIPERDINEDIHYDROCHLORIDE
4-(Piperidin-4-yl)morpholine
CAS: 53617-35-9
Molecular Formula: C9H18N2O
4-MORPHOLINO-PIPERDINEDIHYDROCHLORIDE - Names and Identifiers
| Name | 4-(Piperidin-4-yl)morpholine |
| Synonyms | AKOS BB-9182 CHEMBRDG-BB 4004473 TIMTEC-BB SBB010091 4-Morpholino-piperidin 4-(Piperidin-4-yl)morpholine 4-(PIPERIDIN-4-YL)-MORPHOLINE 4-MORPHOLINO-PIPERDINEDIHYDROCHLORIDE |
| CAS | 53617-35-9 |
| EINECS | 627-580-3 |
| InChI | InChI=1S/C9H18N2O/c1-3-10-4-2-9(1)11-5-7-12-8-6-11/h9-10H,1-8H2 |
4-MORPHOLINO-PIPERDINEDIHYDROCHLORIDE - Physico-chemical Properties
| Molecular Formula | C9H18N2O |
| Molar Mass | 170.25 |
| Density | 1.033±0.06 g/cm3(Predicted) |
| Melting Point | 40-43°C(lit.) |
| Boling Point | 100-115°C0.15-0.20mm Hg(lit.) |
| Flash Point | >230°F |
| Vapor Presure | 0.63-4.58Pa at 25-45℃ |
| Appearance | Solid |
| pKa | 10.21±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| MDL | MFCD03274733 |
4-MORPHOLINO-PIPERDINEDIHYDROCHLORIDE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
4-MORPHOLINO-PIPERDINEDIHYDROCHLORIDE - Reference Information
| LogP | 0.3 at 25℃ and pH11 |
| dissociation constant | 5.44-10.1 at 20 ℃ |
| Application | 4-(4-piperidinyl) morpholine is an organic intermediate, which can be obtained by N-tert-butoxycarbonyl-4-piperidinone and morpholine are reduced and aminated and deprotected. 4-(4-piperidinyl) morpholine can be used to prepare the intermediate 4-{4-ethyl-3-[4-(morpholin-4-yl) piperidin-1-yl] phenyl}-4-methyl-3-oxopentanate tert-butyl ester. |
| preparation | 1) synthesis of compound c16-3: put the compound c16-1(10.0g,50mmol) into a 250mL three-mouth bottle, add anhydrous methanol (100mL), slowly add acetic acid and morpholine (4.78g,55mmol), add palladium carbon (1g.10%), react overnight in hydrogen environment, and the temperament shows that the reaction is complete, spin the solvent, add dichloromethane to dissolve, wash once with a small amount of water, separate the liquid, dry, column chromatography (dichloromethane: methanol = 20:1) to obtain 9g white solid. 2) Synthesis of compound c16-4: Place the compound c16-3(9.0g,33mmol) into a 100mL three-mouth bottle, add 1, 4-dioxane HCl solution, stir, and filter to obtain 9.2g of white solid. The white solid is neutralized with alkali to obtain 4-(4-piperidinyl) morpholine. |
| Uses | 4-(4-piperidinyl) morpholine can be used in biochemical studies to synthesize 2-(4-mercaptoaniline-1-yl)-5-nitrobenzonitrile and 9-bromo-6, 6-dimethyl-8-(4-mercapto-4-yl-piperidin-1-yl)-11-oxo-6,11-Dihydro-5h-benzo (B) cazole-3-carbonylnitrile. Participate in synthesis: • Selective adenosine A2A receptor antagonist • Antidepressants • Small molecules that restore E-cadherin expression and reduce colorectal cancer cell invasion • Oral bioavailable P2Y12 antagonists inhibit platelet aggregation • Quinoline derivatives with antibacterial activity • Antimalarial drugs |
Last Update：2024-04-09 20:52:54
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