4-Methyl-2-pyridinecarbonitrile
2-Cyano-4-methylpyridine
CAS: 1620-76-4
Molecular Formula: C7H6N2
4-Methyl-2-pyridinecarbonitrile - Names and Identifiers
4-Methyl-2-pyridinecarbonitrile - Physico-chemical Properties
| Molecular Formula | C7H6N2 |
| Molar Mass | 118.14 |
| Density | 1.08±0.1 g/cm3(Predicted) |
| Melting Point | 83-87 °C |
| Boling Point | 145-148°C 38mm |
| Flash Point | 145-148°C/38mm |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 0.0117mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Gray to Brown |
| BRN | 110753 |
| pKa | 0.35±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Sensitive | Sensitive to air |
| Refractive Index | 1.531 |
| MDL | MFCD00128868 |
4-Methyl-2-pyridinecarbonitrile - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. S39 - Wear eye / face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | 3276 |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Class | 6.1 |
| Packing Group | III |
4-Methyl-2-pyridinecarbonitrile - Reference Information
| Application | 2-cyano-4-methylpyridine is an organic intermediate, which can be first oxidized from 4-methylpyridine to prepare 4-Methyl-pyridine-N-oxide, and then substituted with cyano group to obtain. 4-methyl-pyridine-N-oxide can be used to prepare 4-methyl -2, 6-dicarboxypyridine, 4-methyl -2, 6-dicarboxypyridine is a very useful pyridine derivative and a very important intermediate compound, which is widely used in the field of pharmacy. |
| preparation | 4-methyl-pyridine-N-oxide (0.109g,1mmol), trimethylcyanosilane (0.119g,1.2mmol),H-diethyl phosphite (0.276g,2mmol), carbon tetrachloride (0.308g,2mmol), triethylamine (0.202g,2mmol) and acetonitrile 10mL in a 50mL three-mouth flask, react at room temperature for 6h. After the reaction is completed, the solvent is removed under reduced pressure and separated by column chromatography (petroleum ether/ethyl acetate, V/V = 4:1) to obtain colorless liquid target compound with 80% yield. |
Last Update：2024-04-09 21:04:16
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