4-Methylpyridazine
4-Methylpyridazine
CAS: 1120-88-3
Molecular Formula: C5H6N2
4-Methylpyridazine - Names and Identifiers
| Name | 4-Methylpyridazine |
| Synonyms | 4-METHYLPYRIDAZINE 4-Methylpyridazine 4-METHYLPYRADIZINE 4-Methyl-1,2-diazine Pyridazine, 4-Methyl- 4-Methylpyridazin-3-aMine |
| CAS | 1120-88-3 |
| InChI | InChI=1/C5H6N2/c1-5-2-3-6-7-4-5/h2-4H,1H3 |
4-Methylpyridazine - Physico-chemical Properties
| Molecular Formula | C5H6N2 |
| Molar Mass | 94.11 |
| Density | 1.06 g/mL at 25 °C (lit.) |
| Melting Point | 105.6℃ |
| Boling Point | 98-100 °C/11 mmHg (lit.) |
| Flash Point | 222°F |
| Vapor Presure | 0.12mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 1.060 |
| Color | Clear yellow |
| Maximum wavelength(λmax) | 292nm(H2O)(lit.) |
| BRN | 105689 |
| pKa | 3.74±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.521(lit.) |
| MDL | MFCD00011594 |
| Physical and Chemical Properties | WGK Germany:3 |
4-Methylpyridazine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29339900 |
4-Methylpyridazine - Introduction
4-methylpyridazine (4-methylpyridazine) is an organic compound with the chemical formula C4H6N2, and the structure contains a methyl group (CH3) and two adjacent azine rings.
Nature:
-Appearance: Colorless to light yellow crystal or crystalline powder
-melting point: 82-85 ℃
-boiling point: 130-132 ℃
-Solubility: 4-methylpyridazine has low solubility in water and is soluble in ethanol, methanol, acetone, acetic acid, ether and other organic solvents.
Use:
- 4-methyl pyridazine can be used as a pharmaceutical intermediate for the synthesis of drugs such as mesylate (Methylphenidate), West afitinib (Sorafenib) and the like.
-It can also be used as a ligand for metal ions, and has certain applications in metal organic chemistry and catalytic reactions.
Preparation Method:
4-Methylpyridazine can be prepared by the following methods:
-It is obtained by reacting 2-methylpyridazine with methylmagnesium bromide and then treating with acid.
-Produced by the dechlorination of 1,4-dimethylpyrazole with dichloromethane.
Safety Information:
-4-Methylpyridazine Irritant, avoid contact with skin, eyes and mucous membranes.
-Avoid direct inhalation or ingestion of the compound during handling and storage.
-Wear appropriate personal protective equipment such as lab gloves and safety goggles when using.
-Follow local regulations and safe operating procedures when storing and handling 4-methylpyridazine.
Nature:
-Appearance: Colorless to light yellow crystal or crystalline powder
-melting point: 82-85 ℃
-boiling point: 130-132 ℃
-Solubility: 4-methylpyridazine has low solubility in water and is soluble in ethanol, methanol, acetone, acetic acid, ether and other organic solvents.
Use:
- 4-methyl pyridazine can be used as a pharmaceutical intermediate for the synthesis of drugs such as mesylate (Methylphenidate), West afitinib (Sorafenib) and the like.
-It can also be used as a ligand for metal ions, and has certain applications in metal organic chemistry and catalytic reactions.
Preparation Method:
4-Methylpyridazine can be prepared by the following methods:
-It is obtained by reacting 2-methylpyridazine with methylmagnesium bromide and then treating with acid.
-Produced by the dechlorination of 1,4-dimethylpyrazole with dichloromethane.
Safety Information:
-4-Methylpyridazine Irritant, avoid contact with skin, eyes and mucous membranes.
-Avoid direct inhalation or ingestion of the compound during handling and storage.
-Wear appropriate personal protective equipment such as lab gloves and safety goggles when using.
-Follow local regulations and safe operating procedures when storing and handling 4-methylpyridazine.
Last Update：2024-04-09 02:00:41
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