4-Morpholinamine
N-Aminomorpholine
CAS: 4319-49-7
Molecular Formula: C4H10N2O
4-Morpholinamine - Names and Identifiers
| Name | N-Aminomorpholine |
| Synonyms | 4-Morpholinamine 4-Aminomonpholine morpholin-4-amine N-Aminomorpholine 4-Aminomorpholine morpholin-4-ylamine Morpholine, 4-amino- 4-Morpholinamine(9CI) 4-ammoniomorpholin-4-ium |
| CAS | 4319-49-7 |
| EINECS | 224-347-4 |
| InChI | InChI=1/C4H12N2O/c5-6-1-3-7-4-2-6/h6H,1-4H2,5H3/q+2 |
4-Morpholinamine - Physico-chemical Properties
| Molecular Formula | C4H10N2O |
| Molar Mass | 102.14 |
| Density | 1.059g/mLat 25°C(lit.) |
| Boling Point | 168°C(lit.) |
| Flash Point | 137°F |
| Water Solubility | miscible |
| Solubility | Chloroform, Methanol (Slightly) |
| Vapor Presure | 1.65mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 1.059 |
| Color | Clear colorless to faintly yellow |
| pKa | pK1: 4.19(+1) (25°C) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Sensitive | Air Sensitive |
| Refractive Index | n20/D 1.4772(lit.) |
| Physical and Chemical Properties | Colorless and transparent. The boiling point is 168 ℃, the relative density is 1.059, the refractive index is 1.4772, and the flash point is 58 ℃. |
4-Morpholinamine - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S23 - Do not breathe vapour. S16 - Keep away from sources of ignition. |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| RTECS | QD7300000 |
| HS Code | 29349990 |
| Hazard Note | Harmful |
| Hazard Class | 3 |
| Packing Group | III |
4-Morpholinamine - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| use | pharmaceutical intermediates. Used in the production of? guide sensitive. |
| Production method | It is obtained from the cyclidation of dichlorodiethyl ether and hydrazine hydrate. Add dichlorodiethyl ether, hydrazine hydrate and ethanol to the reaction tank, slowly raise the temperature under stirring, and reflux for 2 hours. While maintaining reflux, sodium hydroxide was added in batches within 4 hours. Then cool to 10 ℃ for filtration and discard the filter residue. The filtrate recovers ethanol under normal pressure to the 90% of the amount of feed. The reaction solution is cooled to 40-50°C, and sodium hydroxide is added. Stir until sodium hydroxide is dissolved and continue to stir for 30min. Cool to 10-15 ℃, filter and discard the filter residue. The filtrate was extracted twice with toluene (the second extract was applied in the next batch of reactions). After toluene was recovered under reduced pressure, 70-80 ℃(6.67kPa) fractions were collected. The content of more than 20% is a normal boiling substance, namely 4-aminomorpholine. |
Last Update：2024-04-09 15:16:46
