4-N-Boc-3-(Aminomethyl)morpholine

4-N-Boc-3-(Aminomethyl)morpholine - Names and Identifiers

Name	N-Boc-3-aminomethylmorpholine
Synonyms	N-Boc-3-aminomethylmorpholine 4-Boc-3-aminomethylmorpholine 4-N-Boc-3-(Aminomethyl)morpholine tert-Butyl-3-(aminomethyl)morpholin-4-carboxylat tert-butyl 3-(aMinoMethyl)Morpholine-4-carboxylate tert-Butyl 3-(aminomethyl)morpholine-4-carboxylate 3-AMinoMethyl-Morpholine-4-carboxylic acid ert-butyl ester 3-AMINOMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER 3-Aminomethyl-morpholine-4-carboxylic acid tert-butyl ester 3-AMINOMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER HCl 4-morpholinecarboxylic acid, 3-(aminomethyl)-, 1,1-dimethylethyl ester 4-Morpholinecarboxylic acid, 3-(aminomethyl)-, 1,1-dimethylethyl ester
CAS	475106-18-4
InChI	InChI=1/C10H20N2O3/c1-10(2,3)15-9(13)12-4-5-14-7-8(12)6-11/h8H,4-7,11H2,1-3H3

4-N-Boc-3-(Aminomethyl)morpholine - Physico-chemical Properties

Molecular Formula	C10H20N2O3
Molar Mass	216.28
Density	1.078±0.06 g/cm3(Predicted)
Boling Point	310.7±27.0 °C(Predicted)
Flash Point	141.7°C
Vapor Presure	0.000589mmHg at 25°C
pKa	10.01±0.29(Predicted)
Storage Condition	2-8°C(protect from light)
Refractive Index	1.477

4-N-Boc-3-(Aminomethyl)morpholine - Reference Information

use

3-aminomethyl-morpholine -4-butyl carbonate can be used as an intermediate in pharmaceutical synthesis.

preparation

will 3-[(2,2, the mixture of 2-trifluoroethanoamino)-methyl]-morpholin-4-carboxylic acid tert-butyl ester (1.7g) and potassium carbonate (3.77g) in methanol (80ml) and water (27ml) was stirred at ambient temperature for 4 hours, and then heated at 50°C for 2 hours. The reaction mixture was concentrated to remove methanol, diluted with water and extracted with ethyl acetate (x3) and dichloromethane (x4). The combined extract was dried and evaporated to obtain the title product 3-aminomethylmorpholin-4-tert-butyl carbonate (0.97g), which was a yellow jelly.

Last Update：2024-04-10 22:29:15