4-N-Boc-3-aminomethylmorpholine

4-N-Boc-3-aminomethylmorpholine - Names and Identifiers

Name	2-AMINOMETHYL-4-BOC-MORPHOLINE
Synonyms	BUTTPARK 906-25 N-Boc-2-aminomethylmorpholine 4-BOC-2-AMINOMETHYLMORPHOLINE 4-BOC-2-AMINOMETHYLMORPHOLINE 2-AMINOMETHYL-4-BOC-MORPHOLINE 4-N-Boc-3-aminomethylmorpholine 4-N-Boc-2-(2-aminoethyl)morpholine 2-(AMINOMETHYL)MORPHOLINE, 4-BOC PROTECTED TERT-BUTYL 2-(AMINOMETHYL)MORPHOLINE-4-CARBOXYLATE TERTIO-BUTYL 2-(AMINOMETHYL)MORPHOLINE-4-CARBOXYLATE tert-butyl 2-(aminomethyl)morpholine-4-carboxylatato 2-Aminomethyl-morpholine-4-carboxylic acid tert-butyl ester
CAS	140645-53-0
InChI	InChI=1/C10H20N2O3/c1-10(2,3)15-9(13)12-4-5-14-8(6-11)7-12/h8H,4-7,11H2,1-3H3

4-N-Boc-3-aminomethylmorpholine - Physico-chemical Properties

Molecular Formula	C10H20N2O3
Molar Mass	216.28
Density	1.078±0.06 g/cm3(Predicted)
Boling Point	310.7±27.0 °C(Predicted)
Flash Point	141.7°C
Vapor Presure	0.000589mmHg at 25°C
pKa	9.37±0.29(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Refractive Index	1.477

4-N-Boc-3-aminomethylmorpholine - Risk and Safety

Risk Codes	25 - Toxic if swallowed
Safety Description	45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN2811
Hazard Note	Irritant

4-N-Boc-3-aminomethylmorpholine - Introduction

4-Boc-2-(aminomethyl) morpholine, full name N-Boc-N-methylglycinol, is an organic compound with the following properties and uses:

Nature:
1. Appearance: 4-Boc-2-(aminomethyl) morpholine is a white crystalline solid.
2. Solubility: Soluble in some organic solvents, such as dimethylformamide and dichloromethane.
3. molecular structure: the molecular formula is C10H19NO3, the relative molecular mass is 201.26g/mol.

Use:
1. 4-Boc-2-(aminomethyl) morpholine is commonly used as an intermediate in organic synthesis, especially as a removal agent of the protecting group of the compound in the deprotection reaction. It is also used to synthesize drugs and natural products containing N-Boc-N-methylglycinol structures.
3. Sometimes it can also be used as a building block for stereoreceptors (chiral sensors) or ligands (ligands).

Preparation Method:
The method of preparing 4-Boc-2-(aminomethyl) morpholine can be carried out by the following steps:
1. First, chloromethyl morpholine is subjected to a condensation reaction with N-Boc-glycine ester to generate chloromethyl-N-Boc-N-methylglycinol.
2. Next, the product is subjected to condensation reaction with excess sodium carbonate to produce 4-Boc-2-(aminomethyl) morpholine.
3. Finally, the target product is obtained by crystallization or other appropriate purification methods.

Safety Information:
1. 4-Boc-2-(aminomethyl) morpholine is not significantly hazardous under normal conditions of use.
2. in the process of operation, should follow the safety procedures, such as wearing appropriate protective equipment (such as gloves, goggles).
3. This compound may be irritating to the eyes, skin and respiratory system. Avoid contact and inhalation.
4. During storage and handling, it should be stored in a closed container, away from fire and oxidant.

Last Update：2024-04-09 21:01:54