4-N-Boc-3-hydroxymethylmorpholine

Name	4-Boc-2-hydroxymethyl-morpholine
Synonyms	N-Boc-2-hydroxymethylmorpholine 2-Hydroxymethyl-4-Boc-Morpholine 2-HYDROXYMETHYL-4-BOC-MORPHOLINE 4-Boc-2-hydroxymethyl-morpholine N-Boc-2-(hydroxymethyl)morpholine N-BOC-2-(HYDROXYMETHYL)MORPHOLINE 4-N-BOC-2-HYDROXYMETHYLMORPHOLINE 4-N-Boc-3-hydroxymethylmorpholine N-tert-Butoxycarbonyl-2-(hydroxymethyl)morpholine tert-butyl 2-(hydroxymethyl)morpholine-4-carboxylate TERT-BUTYL 2-(HYDROXYMETHYL)MORPHOLINE-4-CARBOXYLATE tert-Butyl 2-(hydroxymethyl)-4-morpholinecarboxylate 2-Hydroxymethyl-morpholine-4-carboxylic acid tert-butyl ester
CAS	135065-69-9
InChI	InChI=1/C10H19NO4/c1-10(2,3)15-9(13)11-4-5-14-8(6-11)7-12/h8,12H,4-7H2,1-3H3

Molecular Formula	C10H19NO4
Molar Mass	217.26
Density	1.118±0.06 g/cm3(Predicted)
Boling Point	320.7±27.0 °C(Predicted)
Flash Point	147.8°C
Solubility	Dichloromethane, Ether, Ethyl Acetate,
Vapor Presure	2.53E-05mmHg at 25°C
Appearance	Oil
Color	Colourless
pKa	14.36±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.474
MDL	MFCD03426270

Hazard Class

IRRITANT

introduction	4-Boc-2-hydroxymethylmorpholine is a pharmaceutical intermediate, which can be obtained by using 4-Boc-2-hydroxymethylmorpholine as raw material. It has been reported that it can be used to prepare compounds that inhibit the activity of Bcl-2 anti-apoptotic proteins.
Preparation	4-Boc-2-hydroxymethylmorpholine can be made of 4-Boc-2-hydroxymethylmorpholine as raw material, through two The step preparation is obtained.
application example	4-Boc-2-hydroxymethylmorphine can be used to prepare compound 2-(1H-pyrrolo [2,3-b] pyridine-5-yloxy)-4-(1-(2-(4-chlorophenyl)-4, 4-Dimethylcyclohexyl-1-enyl) methyl)-1,2,3, 6-tetrahydropyridine-4-yl)-N-(4-((4-(2-(dimethylamine) acetyl) morpholin-2-yl) methylamine)-3-nitrobenzenesulfonyl) benzamide. These compounds are compounds that selectively inhibit the activity of Bcl-2 anti-apoptotic proteins, and can be used to treat diseases related to the expression of anti-apoptotic Bcl-2 proteins.

Last Update：2024-04-09 20:52:54

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