4-Nitro-2,3-dihydro-1H-isoindolin-1-one
4-nitroisoindolin-1-one
CAS: 366452-97-3
Molecular Formula: C8H6N2O3
4-Nitro-2,3-dihydro-1H-isoindolin-1-one - Names and Identifiers
| Name | 4-nitroisoindolin-1-one |
| Synonyms | 4-nitroisoindolin-1-one 4-Nitro-2,3-dihydro-isoindol-1-one 4-nitro-2,3-dihydro-1H-isoindol-1-one 4-Nitro-2,3-dihydro-1H-isoindol-1-one 4-Nitro-2,3-dihydro-1H-isoindolin-1-one 1H-Isoindol-1-one, 2,3-dihydro-4-nitro- |
| CAS | 366452-97-3 |
| InChI | InChI=1/C8H6N2O3/c11-8-5-2-1-3-7(10(12)13)6(5)4-9-8/h1-3H,4H2,(H,9,11) |
4-Nitro-2,3-dihydro-1H-isoindolin-1-one - Physico-chemical Properties
| Molecular Formula | C8H6N2O3 |
| Molar Mass | 178.14 |
| Density | 1.45g/cm3 |
| Boling Point | 488.773°C at 760 mmHg |
| Flash Point | 249.401°C |
| Vapor Presure | 0mmHg at 25°C |
| Storage Condition | Sealed in dry,Room Temperature |
| Sensitive | Irritant |
| Refractive Index | 1.632 |
| MDL | MFCD09701290 |
4-Nitro-2,3-dihydro-1H-isoindolin-1-one - Introduction
4-nitroisoindolin-1-one (4-nitroisoindolin-1-one) is an organic compound with the molecular formula C8H5NO4 and a molecular weight of 183.13g/mol. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 4-nitroisoindolin-1-one as a yellow solid;
-Melting point: about 210 ℃;
-Solubility: Soluble in common solvents such as ethanol, dimethyl ether and chloroform;
-Chemical properties: It is a compound containing nitro (-NO2) groups, so it has high oxidation and explosiveness.
Use:
- 4-nitroisoindolin-1-one is often used as an intermediate in the field of organic synthesis for the synthesis of other biologically active compounds;
-This compound is also used as a precursor for the synthesis of anti-cancer drugs and other small organic molecules in drug research.
Preparation Method:
- 4-nitroisoindolin-1-one is generally prepared by a two-step reaction. First, indoline -1-one and nitric acid nitration reaction, under certain conditions, the formation of 4-nitro-indoline -1-one. This intermediate is then subjected to base treatment and acid neutralization to give the final product 4-nitroisoindolin-1-one.
Safety Information:
- 4-nitroisoindolin-1-one is a chemical and should be stored in a cool, dry and well-ventilated place;
-Due to its high oxidation and explosive properties, it is necessary to comply with strict safety operating procedures when using it, and avoid contact with flammable materials, reducing agents and strong acids;
-Wear appropriate personal protective equipment such as goggles, gloves and protective clothing when handling and manipulating the compound;
-In case of accidental inhalation or contact with skin/eyes, rinse immediately with plenty of water and seek medical attention.
Nature:
-Appearance: 4-nitroisoindolin-1-one as a yellow solid;
-Melting point: about 210 ℃;
-Solubility: Soluble in common solvents such as ethanol, dimethyl ether and chloroform;
-Chemical properties: It is a compound containing nitro (-NO2) groups, so it has high oxidation and explosiveness.
Use:
- 4-nitroisoindolin-1-one is often used as an intermediate in the field of organic synthesis for the synthesis of other biologically active compounds;
-This compound is also used as a precursor for the synthesis of anti-cancer drugs and other small organic molecules in drug research.
Preparation Method:
- 4-nitroisoindolin-1-one is generally prepared by a two-step reaction. First, indoline -1-one and nitric acid nitration reaction, under certain conditions, the formation of 4-nitro-indoline -1-one. This intermediate is then subjected to base treatment and acid neutralization to give the final product 4-nitroisoindolin-1-one.
Safety Information:
- 4-nitroisoindolin-1-one is a chemical and should be stored in a cool, dry and well-ventilated place;
-Due to its high oxidation and explosive properties, it is necessary to comply with strict safety operating procedures when using it, and avoid contact with flammable materials, reducing agents and strong acids;
-Wear appropriate personal protective equipment such as goggles, gloves and protective clothing when handling and manipulating the compound;
-In case of accidental inhalation or contact with skin/eyes, rinse immediately with plenty of water and seek medical attention.
Last Update：2024-04-09 21:04:16
