4-Piperidinecarbonitrile,4-hydroxy-1-(2-phenylethyl)-
4-Hydroxy-1-phenethylpiperidine-4-carbonitrile
CAS: 23804-59-3
Molecular Formula: C14H18N2O
4-Piperidinecarbonitrile,4-hydroxy-1-(2-phenylethyl)- - Names and Identifiers
| Name | 4-Hydroxy-1-phenethylpiperidine-4-carbonitrile |
| Synonyms | BRN 0477606 4-Hydroxy-1-phenethylisonipecotonitrile Isonipecotonitrile, 4-hydroxy-1-phenethyl- 5-22-05-00027 (Beilstein Handbook Reference) 4-Hydroxy-1-phenethylpiperidine-4-carbonitrile 4-Hydroxy-1-phenethyl-4-piperidinecarbonitrile 4-hydroxy-1-phenethylpiperidine-4-carbonitrile 4-Hydroxy-1-(2-phenylethyl)-4-piperidinecarbonitrile 4-hydroxy-1-(2-phenylethyl)piperidine-4-carbonitrile 4-Piperidinecarbonitrile,4-hydroxy-1-(2-phenylethyl)- |
| CAS | 23804-59-3 |
| EINECS | 245-891-9 |
| InChI | InChI=1/C14H18N2O/c15-12-14(17)7-10-16(11-8-14)9-6-13-4-2-1-3-5-13/h1-5,17H,6-11H2 |
4-Piperidinecarbonitrile,4-hydroxy-1-(2-phenylethyl)- - Physico-chemical Properties
| Molecular Formula | C14H18N2O |
| Molar Mass | 230.31 |
| Density | 1.14 |
| Melting Point | 93℃ |
| Boling Point | 419.1±45.0 °C(Predicted) |
| Flash Point | 207.2°C |
| Vapor Presure | 9.01E-08mmHg at 25°C |
| pKa | 11.01±0.20(Predicted) |
| Refractive Index | 1.582 |
4-Piperidinecarbonitrile,4-hydroxy-1-(2-phenylethyl)- - Introduction
It is an organic compound with the chemical formula C16H18N2O. The following is a detailed description of its nature, use, preparation and safety information:
Nature:
-Appearance: White crystalline solid.
-Melting point: About 117-121 degrees Celsius.
-Solubility: Soluble in chloroform, methanol and dichloromethane, slightly soluble in ethanol, almost insoluble in water.
Use:
-is an important synthetic intermediate, which has certain application in the field of drug research.
-It can be used to synthesize a variety of biologically active molecules, such as anti-tumor drugs, analgesic drugs, etc.
Method:
-There are many preparation methods for it. One commonly used method is to start with 4-hydroxy-1-phenylethyl-piperidine:
-First, 4-hydroxy-1-phenylethyl-piperidine is reacted with triethylamine to generate the corresponding salt.
-Then, treat the salt with hydrocyanic acid to form quartz.
Safety Information:
-It has limited toxicity information and therefore requires careful handling and use.
-It may be irritating to the eyes, skin and respiratory system. Avoid direct contact with skin and eyes.
-During use, appropriate laboratory safety measures should be taken, such as wearing laboratory gloves, goggles and protective clothing, and ensuring good ventilation conditions.
-If inhaled or ingested, seek medical attention immediately.
Nature:
-Appearance: White crystalline solid.
-Melting point: About 117-121 degrees Celsius.
-Solubility: Soluble in chloroform, methanol and dichloromethane, slightly soluble in ethanol, almost insoluble in water.
Use:
-is an important synthetic intermediate, which has certain application in the field of drug research.
-It can be used to synthesize a variety of biologically active molecules, such as anti-tumor drugs, analgesic drugs, etc.
Method:
-There are many preparation methods for it. One commonly used method is to start with 4-hydroxy-1-phenylethyl-piperidine:
-First, 4-hydroxy-1-phenylethyl-piperidine is reacted with triethylamine to generate the corresponding salt.
-Then, treat the salt with hydrocyanic acid to form quartz.
Safety Information:
-It has limited toxicity information and therefore requires careful handling and use.
-It may be irritating to the eyes, skin and respiratory system. Avoid direct contact with skin and eyes.
-During use, appropriate laboratory safety measures should be taken, such as wearing laboratory gloves, goggles and protective clothing, and ensuring good ventilation conditions.
-If inhaled or ingested, seek medical attention immediately.
Last Update：2024-04-09 21:01:54
