4-Trifluoromethylbenzyloxyamine hydrochloride
O-[4-(Trifluoromethyl)benzyl]hydroxylamine hydrochloride
CAS: 321574-29-2
Molecular Formula: C8H9ClF3NO
4-Trifluoromethylbenzyloxyamine hydrochloride - Names and Identifiers
4-Trifluoromethylbenzyloxyamine hydrochloride - Physico-chemical Properties
| Molecular Formula | C8H9ClF3NO |
| Molar Mass | 227.61 |
| Melting Point | 325-238°C |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Sensitive | IRRITANT |
| MDL | MFCD00231881 |
4-Trifluoromethylbenzyloxyamine hydrochloride - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Hazard Class | IRRITANT |
4-Trifluoromethylbenzyloxyamine hydrochloride - Introduction
O-[4-(Trifluoromethyl)benzyl]hydroxylamine hydrochloride is an organic compound with the formula C8H8F3NO · HCl. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: White or off-white crystalline solid
-Melting point: approximately 166-168°C
-Solubility: Low solubility in water, soluble in organic solvents such as ethanol and ether
Use:
- O-[4-(Trifluoromethyl)benzyl]hydroxylamine hydrochloride is a commonly used organic synthesis intermediate, commonly used in organic synthesis reaction of amino protecting agent, reducing agent and amino radical donor.
-It can be used to synthesize heterocyclic compounds, nitrogen-containing heterocyclic derivatives, amino compounds, etc.
Preparation Method:
The preparation of O-[4-(Trifluoromethyl)benzyl]hydroxylamine hydrochloride can be carried out by the following steps:
-Reaction of trifluoromethyl anisole with bromoacetate to give the corresponding acid ester compound.
-The acid ester compound is reduced by sodium borohydride to obtain trifluoromethylbenzoxylamine.
-Finally, trifluoromethylbenzoxylamine is reacted with hydrochloric acid to prepare O-[4-(Trifluoromethyl)benzyl]hydroxylamine hydrochloride.
Safety Information:
- O-[4-(Trifluoromethyl)benzyl]hydroxylamine hydrochloride are stored and used in accordance with general laboratory safety practices.
-Avoid contact with skin and eyes, wear protective gloves and goggles if necessary.
-Avoid inhaling the dust or gas of the solution, and use it in a well-ventilated place.
-storage should be placed in a dry, cool, ventilated place.
Nature:
-Appearance: White or off-white crystalline solid
-Melting point: approximately 166-168°C
-Solubility: Low solubility in water, soluble in organic solvents such as ethanol and ether
Use:
- O-[4-(Trifluoromethyl)benzyl]hydroxylamine hydrochloride is a commonly used organic synthesis intermediate, commonly used in organic synthesis reaction of amino protecting agent, reducing agent and amino radical donor.
-It can be used to synthesize heterocyclic compounds, nitrogen-containing heterocyclic derivatives, amino compounds, etc.
Preparation Method:
The preparation of O-[4-(Trifluoromethyl)benzyl]hydroxylamine hydrochloride can be carried out by the following steps:
-Reaction of trifluoromethyl anisole with bromoacetate to give the corresponding acid ester compound.
-The acid ester compound is reduced by sodium borohydride to obtain trifluoromethylbenzoxylamine.
-Finally, trifluoromethylbenzoxylamine is reacted with hydrochloric acid to prepare O-[4-(Trifluoromethyl)benzyl]hydroxylamine hydrochloride.
Safety Information:
- O-[4-(Trifluoromethyl)benzyl]hydroxylamine hydrochloride are stored and used in accordance with general laboratory safety practices.
-Avoid contact with skin and eyes, wear protective gloves and goggles if necessary.
-Avoid inhaling the dust or gas of the solution, and use it in a well-ventilated place.
-storage should be placed in a dry, cool, ventilated place.
Last Update：2024-04-10 22:29:15
