4-amino-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-5-methylpyrimidin-2(1H)-one
5-methyl-2'-methoxyethoxycytosine
CAS: 244105-55-3
Molecular Formula: C13H21N3O6
4-amino-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-5-methylpyrimidin-2(1H)-one - Names and Identifiers
| Name | 5-methyl-2'-methoxyethoxycytosine |
| Synonyms | -methoxyethoxycytosine 5-Methyl-2'-methoxyethoxycytosine 5-methyl-2'-methoxyethoxycytosine 2'-O-(2-Methoxyethyl)-5-Methyl- cytidine 2'-O-(2-Methoxyethyl)-5-Methyl- Cytidine Cytidine, 2'-O-(2-Methoxyethyl)-5-Methyl- 4-((2-Methoxyethoxy)aMino)-5-MethylpyriMidin-2(1H)-one 4-amino-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-5-methylpyrimidin-2(1H)-one |
| CAS | 244105-55-3 |
4-amino-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-5-methylpyrimidin-2(1H)-one - Physico-chemical Properties
| Molecular Formula | C13H21N3O6 |
| Molar Mass | 315.32 |
| Density | 1.52 |
| Melting Point | >70°C(dec) |
| Boling Point | 536.5±60.0 °C(Predicted) |
| Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| Appearance | Solid |
| Color | Off-White to Light Yellow |
| pKa | 13.36±0.70(Predicted) |
| Storage Condition | 2-8°C |
4-amino-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-5-methylpyrimidin-2(1H)-one - Introduction
5-methyl-2 '-methoxyethoxycytosine is an organic compound with the chemical formula C10H15N3O3. The following is a description of some properties, uses, preparation and safety information about the compound:
Nature:
-Appearance: White crystalline solid
-melting point: about 190-194 degrees Celsius
-Solubility: Soluble in water, alcohols and some organic solvents, such as chloroform and methanol.
Use:
- 5-methyl-2 '-methoxyethoxycytosine is a locked nucleic acid (LNA).
- LNA molecules have high affinity and stability, and can be used to enhance the selectivity and affinity of nucleic acid sequences.
- 5-methyl-2 '-methoxyethoxycytosine can be used to design and synthesize highly efficient DNA or RNA probes for molecular recognition, genetic testing, and drug discovery.
Preparation Method:
The preparation of -5-methyl-2 '-methoxyethoxycytosine is usually by introducing a methyl group at the 5-position of the cytosine molecule, and then introducing methoxy and ethoxy groups at the 2'-and 5-positions.
Safety Information:
-Due to the high use of this compound in the laboratory, there are not many reports on its toxicity and safety.
-In general, however, laboratory safety practices should be followed when using any chemical, including the proper wearing of personal protective equipment, avoiding inhalation, contact or ingestion, and proper storage and disposal of the compound.
Nature:
-Appearance: White crystalline solid
-melting point: about 190-194 degrees Celsius
-Solubility: Soluble in water, alcohols and some organic solvents, such as chloroform and methanol.
Use:
- 5-methyl-2 '-methoxyethoxycytosine is a locked nucleic acid (LNA).
- LNA molecules have high affinity and stability, and can be used to enhance the selectivity and affinity of nucleic acid sequences.
- 5-methyl-2 '-methoxyethoxycytosine can be used to design and synthesize highly efficient DNA or RNA probes for molecular recognition, genetic testing, and drug discovery.
Preparation Method:
The preparation of -5-methyl-2 '-methoxyethoxycytosine is usually by introducing a methyl group at the 5-position of the cytosine molecule, and then introducing methoxy and ethoxy groups at the 2'-and 5-positions.
Safety Information:
-Due to the high use of this compound in the laboratory, there are not many reports on its toxicity and safety.
-In general, however, laboratory safety practices should be followed when using any chemical, including the proper wearing of personal protective equipment, avoiding inhalation, contact or ingestion, and proper storage and disposal of the compound.
Last Update：2024-04-09 21:04:16
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