4-bromo-6-hydroxy-1-isoindolinone

4-bromo-6-hydroxy-1-isoindolinone - Names and Identifiers

Name	1H-Isoindol-1-one, 4-bromo-2,3-dihydro-6-hydroxy-
Synonyms	4-BroMo-6-hydroxyisoindolin-1-one 4-bromo-6-hydroxy-1-isoindolinone 4-BroMo-6-hydroxy-2,3-dihydro-isoindol-1-one 4-Bromo-6-hydroxy-2,3-dihydro-1H-isoindol-1-one 1H-Isoindol-1-one, 4-bromo-2,3-dihydro-6-hydroxy- 1H-Isoindol-1-one, 4-broMo-2,3-dihydro-6-hydroxy-
CAS	808127-76-6

4-bromo-6-hydroxy-1-isoindolinone - Physico-chemical Properties

Molecular Formula	C8H6BrNO2
Molar Mass	228.04
Storage Condition	2-8°C

4-bromo-6-hydroxy-1-isoindolinone - Reference Information

Use

4-bromo-6-hydroxyisoindolin-1-one is an organic intermediate, it is reported to be useful for the preparation of tyrosine protease inhibitors.

preparation

4-bromo-6-hydroxyisoindolin-1-one from 4-bromo-6-methoxyisoindolin-1-one the starting material is obtained by hydrolysis of the methoxy group. To 4-bromo-6-methoxyisoindolin-1-one (100mg,0.41mmol) in dichloromethane (13mL) with stirring at -78 °c. 1M solution of BBr 3 in dichloromethane (1.2mL,1.2mmol) was added dropwise to the suspension in. The mixture was stirred for 1 hour and at room temperature for 2 hours. The mixture was treated with additional 1m BBr 3(0.8mL) in dichloromethane, heated to reflux overnight, then cooled to room temperature, and partitioned between water and ethyl acetate. The organic phase was dried (Na2SO4), filtered and concentrated to give the desired product. Yield 91mg,97%.

Last Update：2024-04-09 21:00:56