4-chloro-5-fluoropyrimidin-2-amine

4-chloro-5-fluoropyrimidin-2-amine - Names and Identifiers

Name	Pyrimidine, 2-amino-4-chloro-5-fluoro- (7CI,8CI)
Synonyms	4-Chloro-5-fluoro-2-pyrimidinamine 4-chloro-5-fluoropyrimidin-2-amine 2-Amino-4-chloro-5-fluoropyrimidine 2-PyriMidinaMine, 4-chloro-5-fluoro- PyriMidine, 2-aMino-4-chloro-5-fluoro- Pyrimidine, 2-amino-4-chloro-5-fluoro- (7CI,8CI)
CAS	1683-75-6
EINECS	205-525-8

4-chloro-5-fluoropyrimidin-2-amine - Physico-chemical Properties

Molecular Formula	C4H3ClFN3
Molar Mass	147.54
Density	1.564±0.06 g/cm3(Predicted)
Melting Point	110 °C (decomp)
Boling Point	321.7±45.0 °C(Predicted)
pKa	1.92±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C

4-chloro-5-fluoropyrimidin-2-amine - Introduction

Pyrimidine, 2-amino-4-chloro-5-fluoro- (7CI,8CI), chemical formula C4H4ClFN4.

Nature:
Pyrimidine, 2-amino-4-chloro-5-fluoro- (7CI,8CI) is an organic compound. It is a colorless crystalline solid, stable at room temperature. It is less soluble in water, but more soluble in organic solvents such as ethanol and dichloromethane.

Use:
Pyrimidine, 2-amino-4-chloro-5-fluoro- (7CI,8CI) has important applications in drug synthesis. It is a key intermediate in anticancer drugs and can be used to synthesize a variety of anticancer drugs, including bromomycin (bcg), mitomycin C(CCNU), etc.

Method:
Pyrimidine, 2-amino-4-chloro-5-fluoro- (7CI,8CI) can be prepared in various ways. One of the commonly used methods is to replace the chlorine atom with an amino group by reacting 2-amino-5-fluoropyrimidine with carbon tetrachloride and then by the action of ammonia or other base.

Safety Information:
Pyrimidine, 2-amino-4-choro-5-fluoro- (7CI,8CI) is generally relatively safe under normal conditions of use. However, as a chemical, correct handling and warehousing methods are still very important. It should avoid contact with strong oxidants and strong acids and should be stored in a dry, cool place. At the same time, wear appropriate personal protective equipment, such as laboratory gloves and goggles, to prevent contact with skin and eyes. If you accidentally take or come into contact with a large amount of Pyrimidine, 2-amino-4-chloro-5-fluoro- (7CI,8CI), seek medical attention immediately. Proper handling, storage and disposal methods can reduce potential risks.

Last Update：2024-04-09 21:11:58