Name | 4-chlorokynurenine |
Synonyms | 4-chlorokynurenine 2-amino-4-(2-amino-4-chlorophenyl)-4-oxobutanoic acid |
CAS | 75802-84-5 |
Molecular Formula | C10H11ClN2O3 |
Melting Point | >165°C (dec.) |
Solubility | Aqueous Acid (Slightly), DMSO (Sparingly) |
Appearance | Solid |
Color | Pale Yellow to Yellow |
Storage Condition | Refrigerator |
use | 7-Cl-Kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readil y enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application. |