4-isothiocyanato-2-(trifluoroMethyl)benzonitrile
3-Fluoro-4-methylphenylisothiocyanate
CAS: 143782-23-4
Molecular Formula: C9H3F3N2S
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile - Names and Identifiers
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile - Physico-chemical Properties
| Molecular Formula | C9H3F3N2S |
| Molar Mass | 228.194 |
| Density | 1.31 |
| Melting Point | 39.0 to 43.0 °C |
| Boling Point | 331℃ |
| Flash Point | 154℃ |
| Storage Condition | 2-8℃ |
| Use | 4-isothiocyanato-2-(trifluoromethyl) benzonitrile is a reagent for the synthesis of thiimidazolidinone compounds and is a potential anti-prostate cancer drug. Also used for enzalutamide intermediates. |
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile - Upstream Downstream Industry
| Downstream Products | 4-(3-(4-hydroxyphenyl)-4,4-diMethyl-5-oxo-2-thioxoiMidazolidin-1-yl)-2-(trifluoroMethyl)benzonitrile |
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile - Introduction
It is an organic compound with the chemical formula C8HF3N2S.
Nature:
-Appearance: Colorless crystal or white powder.
-Solubility: Soluble in organic solvents, such as ethanol, chloroform, etc., insoluble in water.
-Melting point: About 80-85 degrees Celsius.
-Stability: relatively stable at room temperature, but will decompose in the presence of high temperature, light and oxygen.
Use:
-pesticide intermediates: can be used for synthetic pesticides, such as fungicides, insecticides, etc.
-Pharmaceutical field: It can also be used as a drug intermediate for the synthesis of drugs.
Method:
The synthesis method includes the following steps:
1. Reacting O-difluorobenzene with trifluoromethyl isothiocyanate to give 4-isothiocyano-2-(trifluoromethyl) phenol.
2. The above product can be obtained by reacting with Cyanogen chloride.
Safety Information:
-may have certain toxicity to the human body, should pay attention to protective measures.
-Avoid contact with skin and eyes during operation, and wear protective gloves, safety glasses and other personal protective equipment if necessary.
-operation should be carried out in a well-ventilated environment, avoid inhalation of its vapor.
-should be stored away from the fire and oxidant, keep sealed, stored in a cool, dry place.
-Waste shall be disposed of in accordance with relevant laws and regulations and shall not be discarded at will.
Nature:
-Appearance: Colorless crystal or white powder.
-Solubility: Soluble in organic solvents, such as ethanol, chloroform, etc., insoluble in water.
-Melting point: About 80-85 degrees Celsius.
-Stability: relatively stable at room temperature, but will decompose in the presence of high temperature, light and oxygen.
Use:
-pesticide intermediates: can be used for synthetic pesticides, such as fungicides, insecticides, etc.
-Pharmaceutical field: It can also be used as a drug intermediate for the synthesis of drugs.
Method:
The synthesis method includes the following steps:
1. Reacting O-difluorobenzene with trifluoromethyl isothiocyanate to give 4-isothiocyano-2-(trifluoromethyl) phenol.
2. The above product can be obtained by reacting with Cyanogen chloride.
Safety Information:
-may have certain toxicity to the human body, should pay attention to protective measures.
-Avoid contact with skin and eyes during operation, and wear protective gloves, safety glasses and other personal protective equipment if necessary.
-operation should be carried out in a well-ventilated environment, avoid inhalation of its vapor.
-should be stored away from the fire and oxidant, keep sealed, stored in a cool, dry place.
-Waste shall be disposed of in accordance with relevant laws and regulations and shall not be discarded at will.
Last Update：2024-04-09 02:00:42
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View History
Downstream Products for 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile
4-(3-(4-hydroxyphenyl)-4,4-diMethyl-5-oxo-2-thioxoiMidazolidin-1-yl)-2-(trifluoroMethyl)benzonitrile