4-methyl-2-(piperidin-1-yl)quinoline
4-Methyl-2-(1-piperidinyl)-quinoline
CAS: 5465-86-1
Molecular Formula: C15H18N2
4-methyl-2-(piperidin-1-yl)quinoline - Names and Identifiers
4-methyl-2-(piperidin-1-yl)quinoline - Physico-chemical Properties
| Molecular Formula | C15H18N2 |
| Molar Mass | 226.32 |
| Density | 1.102±0.06 g/cm3(Predicted) |
| Melting Point | 72-73 °C |
| Boling Point | 177-180 °C(Press: 4.5 Torr) |
| Solubility | DMSO: soluble5mg/mL at warmed (clear solution) |
| Appearance | powder |
| Color | white to beige |
| pKa | 7.34±0.61(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | ML204 inhibits TRPC4β-mediated elevation of intracellular calcium with an IC50 of 0.96 μm, which is 19-fold more selective for muscarinic receptor-coupled TPRC6 channels. The inhibition of TPRC4β by ML204 is independent of GPCR activation. Selective experiments showed that 10-20 μm ML204 had no significant inhibitory effect on TRPV1, TRPV3, TRPA1, TRPM8 and KCNQ2 and voltage-dependent sodium ion channels, potassium ion channels and calcium ion channels in mouse dorsal root ganglion neurons. ML204 inhibits TRPC4β activity induced by G I/o or G q/11 stimulation |
| In vivo study | ML204 (1 mg/kg; s.c.; twice a day; for 5 days) causes mortality associated with exacerbated hypothermia and decreases peritoneal leukocyte numbers and cytokines in LPS-injected mice. Animal Model: Nonfasted male C57BL/6 (2-3 months) Dosage: 1 mg/kg Administration: Subcutaneous injection, twice a day, for 5 days (prior to LPS injection) Result: Induced mortality associated with increased hypothermia in mice with LPS-induced systemic inflammatory response. |
4-methyl-2-(piperidin-1-yl)quinoline - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
4-methyl-2-(piperidin-1-yl)quinoline - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.419 ml | 22.093 ml | 44.185 ml |
| 5 mM | 0.884 ml | 4.419 ml | 8.837 ml |
| 10 mM | 0.442 ml | 2.209 ml | 4.419 ml |
| 5 mM | 0.088 ml | 0.442 ml | 0.884 ml |
Last Update：2024-01-02 23:10:35
4-methyl-2-(piperidin-1-yl)quinoline - Introduction
4-Methyl-2-(1-piperidinyl)-quinoline is an organic compound with the chemical formula C16H19N2, which is a white solid.
This compound has many uses. It is widely studied in the field of medicine and is considered to have anti-cancer, antibacterial and other activities. In addition, it can also be used as a metal ion detector, and can also be used in the fields of fluorescent dyes and photosensitizers.
There are various methods for preparing 4-Methyl-2-(1-piperidinyl)-quinoline. One method is by the condensation of methyl quinolin-2-ylamine and 1-piperidinecarboxaldehyde. This reaction is typically carried out in a hot alcoholic solvent with the addition of a suitable acid catalyst.
Regarding safety information, 4-Methyl-2-(1-piperidinyl)-quinoline has not been thoroughly toxicologically studied in many studies, so its toxicity and danger are not fully known. As a chemical, users should take appropriate protective measures when handling, avoid skin contact, inhalation or ingestion. Laboratory safety procedures should also be followed when using the compound. The relevant safety data forms or material safety specifications should be read and observed before use. In case of discomfort or accident, seek medical attention immediately and hold relevant materials for reference.
This compound has many uses. It is widely studied in the field of medicine and is considered to have anti-cancer, antibacterial and other activities. In addition, it can also be used as a metal ion detector, and can also be used in the fields of fluorescent dyes and photosensitizers.
There are various methods for preparing 4-Methyl-2-(1-piperidinyl)-quinoline. One method is by the condensation of methyl quinolin-2-ylamine and 1-piperidinecarboxaldehyde. This reaction is typically carried out in a hot alcoholic solvent with the addition of a suitable acid catalyst.
Regarding safety information, 4-Methyl-2-(1-piperidinyl)-quinoline has not been thoroughly toxicologically studied in many studies, so its toxicity and danger are not fully known. As a chemical, users should take appropriate protective measures when handling, avoid skin contact, inhalation or ingestion. Laboratory safety procedures should also be followed when using the compound. The relevant safety data forms or material safety specifications should be read and observed before use. In case of discomfort or accident, seek medical attention immediately and hold relevant materials for reference.
Last Update：2024-04-09 20:52:54
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CAS: 5465-86-1
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QQ: 3008007409
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CAS: 5465-86-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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