4-nitro-n-methylaniline
N-Methyl-4-nitroaniline
CAS: 100-15-2
Molecular Formula: C7H8N2O2
4-nitro-n-methylaniline - Names and Identifiers
| Name | N-Methyl-4-nitroaniline |
| Synonyms | Nitronaniline Methyl-4-nitroaniline Intedanib Impurity 10 4-nitro-n-methylaniline N-Methyl-4-nitroaniline N-Methyl-p-nitroaniline 4-nitro-N-methylaniline N1-methyl-4-nitroaniline 4-METHYLAMINONITROBENZENE 1-METHYLAMINO-4-NITROBENZENE p-(methylamino)nitrobenzene N-monomethyl-p-nitroaniline |
| CAS | 100-15-2 |
| EINECS | 202-823-2 |
| InChI | InChI=1/C7H8N2O2/c1-8-6-2-4-7(5-3-6)9(10)11/h2-5,8H,1H3 |
| InChIKey | XIFJZJPMHNUGRA-UHFFFAOYSA-N |
4-nitro-n-methylaniline - Physico-chemical Properties
| Molecular Formula | C7H8N2O2 |
| Molar Mass | 152.15 |
| Density | 1.2010 |
| Melting Point | 149-151°C(lit.) |
| Boling Point | 294.61°C (rough estimate) |
| Flash Point | 129.5°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.00205mmHg at 25°C |
| Vapor Density | 5.25 (vs air) |
| Appearance | Solid |
| Color | Yellow to Very Dark Yellow |
| BRN | 637920 |
| pKa | 0.56±0.12(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.6276 (estimate) |
| Physical and Chemical Properties | Brown yellow prismatic crystals with violet light. Melting point 152 °c. Soluble in acetone, benzene, ethanol-soluble, insoluble in water. |
| Use | Used as a dye intermediate |
4-nitro-n-methylaniline - Risk and Safety
| Risk Codes | R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R33 - Danger of cumulative effects R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | 2811 |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29214200 |
| Hazard Note | Highly Toxic/Irritant |
| Hazard Class | 6.1 |
| Packing Group | III |
4-nitro-n-methylaniline - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| uses | for organic synthesis, dye intermediates. used as dye intermediate |
| production method | is prepared from p-nitroacetanilide, methyl iodide and ethanol as raw materials. Acetone, P-nitroacetanilide and potassium hydroxide were mixed, followed by heating and refluxing, and an acetone solution of methyl iodide was added dropwise. After addition, refluxing was continued for 4 hours. After standing overnight, the acetone was recovered, and crystals were precipitated. After cooling, the alkali was washed off and washed with ethanol to obtain N-methyl-p-nitroacetanilide. Then it was mixed with ethanol and hydrochloric acid, heated and refluxed for 8H to recover ethyl acetate and ethanol, washed with water, washed with acid, and dried to obtain crude product. The crude product is dissolved with acetone, filtered, and the recovered acetone is precipitated to be the finished product. |
Last Update：2024-04-09 19:55:45
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