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4-sulfanilamido-5,6-dimethoxypyrimidine

sulfadoxine

CAS: 2447-57-6

Molecular Formula: C12H14N4O4S

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  5. 4-sulfanilamido-5,6-dimethoxypyrimidine

4-sulfanilamido-5,6-dimethoxypyrimidine - Names and Identifiers

Name sulfadoxine
Synonyms Fanzil
Fanasil
fanasil
sulfadoxine
Sulphadoxine
Sulforthomidine
Sulformethoxine
sulforthomidine
Sulfadimoxine Fanasil
4-Sulfanilamido-5,6-dimethoxypyrimidine
4-sulfanilamido-5,6-dimethoxypyrimidine
Fansidar (suldfadoxine and pyrimethamine)
N-(5,6-Dimethoxy-4-pyrimidinyl)sulfanilamide
N'-(5,6-Dimethoxy-4-pyrimidinyl)sulfanilamide
N1-(5,6-dimethoxypyrimidin-4-yl)sulphanilamide
6-(4-aminobenzenesulfonamido)-4,5-dimethoxypyrimidine
6-(4-Aminobenzenesulfonamido)-4,5-dimethoxypyrimidine
6-(4-Aminobenzenesulfonamide)-4,5-dimethoxypyrimidine
6-(4-aminobenzenesulfonamide)-4,5-dimethoxypyrimidine
4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide
4-amino-n-(5,6-dimethoxy-4-pyrimidinyl)-benzenesulfonamid
4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide
4-AMINO-N-(5,6-DIMETHOXY-4-PYRIMIDINYL)BENZENESULFONAMIDE
CAS 2447-57-6
EINECS 219-504-9
InChI InChI=1/C12H14N4O4S/c1-19-10-11(14-7-15-12(10)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)

4-sulfanilamido-5,6-dimethoxypyrimidine - Physico-chemical Properties

Molecular FormulaC12H14N4O4S
Molar Mass310.33
Density1.4006 (rough estimate)
Melting Point190-194°C
Boling Point298°C (rough estimate)
Flash Point270°C
Water Solubility209.8mg/L(temperature not stated)
Solubility Soluble in dilute acid or lye, slightly soluble in acetone, slightly soluble in ethanol, almost insoluble in water.
Vapor Presure5.01E-11mmHg at 25°C
AppearanceWhite or white-like crystalline powder
Colorwhite
Merck14,8906
BRN625453
pKa6.16±0.50(Predicted)
Storage ConditionKeep in dark place,Inert atmosphere,Room temperature
Refractive Index1.6270 (estimate)
MDLMFCD00792890
Physical and Chemical PropertiesMelting Point: 190 - 194
UseUltra-Long-acting sulfonamides for the treatment of meningitis, urinary tract infections
In vitro study Sulfadoxine(Sulphadoxine) is an ultra-long-lasting sulfonamide. Sulfadoxine is often used in combination with pyrimethamine to treat or prevent malaria. Both drugs are antifolates; they inhibit the production of enzymes involved in the synthesis of folic acid within the parasites. Either drug by itself is only moderately effective in treating malaria, because the parasite Plasmodium falciparum may be able to use exogenous folic acid, i.e. folic acid which is present in the parasite's environment, while in combination, the two substances have a synergistic effect which outbalances that ability [1, 2].

4-sulfanilamido-5,6-dimethoxypyrimidine - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany2
RTECSDA9500000
HS Code29350090
ToxicityLD50 in mice (microcrystals, mg/kg): 5200 orally, 2900 s.c., 2900 i.p. (Bhni)

4-sulfanilamido-5,6-dimethoxypyrimidine - Reference

Reference
Show more
1. [IF=4.821] Jin-Ye Lang et al."Preparation of boronate-modified larger mesoporous polymer microspheres with fumed silica nanoparticle and toluene as synergistic porogen for selective separation of sulfonamides."Microchem J. 2022 Apr;175:107193

4-sulfanilamido-5,6-dimethoxypyrimidine - Introduction

The light gradually changes color, almost odorless. The taste is slightly bitter. Soluble in dilute acid or lye, slightly soluble in acetone, slightly soluble in ethanol, almost insoluble in water.
Last Update：2022-10-16 17:15:14

4-sulfanilamido-5,6-dimethoxypyrimidine - Reference Information

Introduction Zhou Xiao Sulfonamide alias Zhou Xiao Sulfonamide, Sulfadoxine, Sulfamethoxine. It is a white or white-like crystalline powder. It is mainly used for tracheitis, pneumonia, bacillary dysentery, urinary tract infection, skin and soft tissue infection and prevention of rheumatic fever.
use sulfonamide is generally used for the treatment of inflammation, such as upper respiratory tract infection tonsillitis, bacillary dysenteritis, skin infection, etc. It can also be combined with other drugs to treat tuberculosis and lymphatic tuberculosis.
Ultra-long-acting sulfa-like drugs for the treatment of meningitis, urinary tract infections, etc.
biological activity Sulfadoxine (Sulphadoxine) is an ultra-long-acting sulfa drug that acts on P. Vivax with IC50 of 249 μg/ml.
category toxic substances
toxicity classification poisoning
acute toxicity oral administration-mouse LD50: 5200 mg/kg; Abdominal cavity-mouse LD50: 2900 mg/kg
flammability hazard characteristics combustible; combustion produces toxic nitrogen oxides and sulfur oxide smoke
storage and transportation characteristics warehouse ventilation and low temperature drying
fire extinguishing agent dry powder, foam, sand, carbon dioxide, mist water
Last Update：2024-04-10 22:29:15
4-sulfanilamido-5,6-dimethoxypyrimidine
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Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: sulfadoxine Request for quotation
CAS: 2447-57-6
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: sulfadoxine Request for quotation
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: sulfadoxine Request for quotation
CAS: 2447-57-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Sulfadoxin Visit Supplier Webpage Request for quotation
CAS: 2447-57-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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4-sulfanilamido-5,6-dimethoxypyrimidine
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