4-trifluoromethyl-2(1H)-quinolinone

4-trifluoromethyl-2(1H)-quinolinone - Names and Identifiers

Name	2-Hydroxy-4-(trifluoromethyl)quinoline
Synonyms	4-(Trifluoromethyl)quinolin-2-ol 4-Trifluoromethyl-1H-quinolin-2-one 4-trifluoromethyl-2(1H)-quinolinone 4-(trifluoromethyl)quinolin-2(1H)-one 2-Hydroxy-4-(trifluoromethyl)quinoline 2-hydroxy-4-(trifluoroMethyl)quinqline 2-HYDROXY-4-(TRIFLUOROMETHYL)QUINOLINE 4--(TrifluoroMethyl)quinoline-2(H)-one
CAS	25199-84-2
InChI	InChI=1/C10H6F3NO/c11-10(12,13)7-5-9(15)14-8-4-2-1-3-6(7)8/h1-5H,(H,14,15)

4-trifluoromethyl-2(1H)-quinolinone - Physico-chemical Properties

Molecular Formula	C10H6F3NO
Molar Mass	213.16
Density	1.391
Melting Point	>240°C
Boling Point	284 ºC
Flash Point	126 ºC
Vapor Presure	0.00304mmHg at 25°C
Appearance	Solid
Color	White
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.516

4-trifluoromethyl-2(1H)-quinolinone - Risk and Safety

Safety Description	24/25 - Avoid contact with skin and eyes.
HS Code	29339900

4-trifluoromethyl-2(1H)-quinolinone - Introduction

2-Hydroxy-4-(trifluoromethyl)quinoline is an organic compound with the chemical formula C10H6F3NO. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: 2-Hydroxy-4-(trifluoromethyl)quinoline is a colorless to pale yellow solid.
-Solubility: It can be dissolved in organic solvents (such as alcohols, ethers and ketones).
-Melting point: Its melting point is about 80°C to 85°C.
-Stability: It is a relatively stable compound, but it may decompose under strong oxidants and high temperature conditions.

Use:
-Drug research: 2-Hydroxy-4-(trifluoromethyl)quinoline has a wide range of uses in the pharmaceutical field. It is used as a synthetic intermediate for antibacterial, antiviral, anti-inflammatory and anti-tumor drugs.
-Pesticide research: It is also used as an intermediate for the synthesis of pesticides, with insecticidal and fungicidal activities.

Method:
The preparation method of 2-Hydroxy-4-(trifluoromethyl)quinoline includes the following steps:
1. Under alkaline conditions, 2-chloroquinoline reacts with trifluoromethanol to generate 2-Hydroxy-4-(trifluoromethyl)quinoline.

Safety Information:
Specific toxicity data for -2-Hydroxy-4-(trifluoromethyl)quinoline are scarce. Generally speaking, it should be regarded as a hazardous material, and appropriate protective measures should be taken when exposed, such as wearing protective gloves and glasses.
-Inhalation or skin contact may cause discomfort. Contact with skin and eyes should be avoided. In case of accidental contact, rinse immediately with plenty of water and seek medical help.
-During use or handling, good ventilation conditions should be maintained to avoid inhalation of its vapor.
-During storage and handling, avoid contact with oxidants, strong acids, strong alkalis, and high temperatures, and keep the container sealed.

Please note that this information is for informational purposes only and more comprehensive information may be required for specific nature, use, manufacturing and safety information. When using this compound, it is recommended to follow the relevant safety practices and follow the relevant laws and regulations.

Last Update：2024-04-09 15:17:56