4-氨基-2-氟苯腈
4-Amino-2-fluorobenzonitrile
CAS: 53312-80-4
Molecular Formula: C7H5FN2
4-氨基-2-氟苯腈 - Names and Identifiers
| Name | 4-Amino-2-fluorobenzonitrile |
| Synonyms | ZR CF DCN ZR CF DCN [WLN] 4-Cyano-3-fluoroaniline Fluoro-4-amino-benzonitrile 4-Amino-2-fluorobenzonitrile 4-AMINO-2-FLUOROBENZONITRILE Benzonitrile, 4-amino-2-fluoro- |
| CAS | 53312-80-4 |
| InChI | InChI=1/C7H5FN2/c8-7-3-6(10)2-1-5(7)4-9/h1-3H,10H2 |
4-氨基-2-氟苯腈 - Physico-chemical Properties
| Molecular Formula | C7H5FN2 |
| Molar Mass | 136.13 |
| Density | 1.25±0.1 g/cm3(Predicted) |
| Boling Point | 288.2±25.0 °C(Predicted) |
| Flash Point | 128.1°C |
| Vapor Presure | 0.00237mmHg at 25°C |
| Appearance | Black crystal |
| pKa | 0.71±0.10(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| Refractive Index | 1.56 |
| MDL | MFCD07368709 |
4-氨基-2-氟苯腈 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Hazard Class | IRRITANT |
4-氨基-2-氟苯腈 - Reference Information
| introduction | 4-amino-2-fluorobenzonitrile is an organic intermediate, which can be prepared by the reaction of 4-bromo-3-fluoroaniline and Zn(CN)2. |
| Preparation | The mixture of 2-fluoro-4-nitrobenzonitrile (8.31g,50mmol) and tin chloride dihydrate (56.4g,250mmol) in 250mL EtOAc was heated overnight at 25°C. LCMS(78109-084) indicates that the reaction is complete. 25mL saturated K2CO3 was added to the reaction mixture. The resulting mixture was stirred at room temperature for 2h and then 100g of solid K2CO3 was added. Stir the mixture at room temperature for 2 hours. The solids are removed by filtration and further washed with EtOAc(50 mLx2). The filtrate was concentrated to obtain 6.81g(100%) 4-amino-2-fluorobenzonitrile, which is an off-white solid. |
Last Update：2024-04-09 15:16:39
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View History
4-氨基-2-氟苯腈
15-Methylhexadecanoic acid methyl ester, 15-Methylpalmitic acid methyl ester
2-(吡啶基甲基)三苯基溴化膦
替罗非班杂质丁二盐酸盐
POLYDIMETHYLSILOXANE, VINYLDIMETHYLSILOXY TERMINATED
4-Isopropyl-1H-pyrazole hydrochloride
Domperidone impurities1449
(R-type) ginsenoside Rh2
4-Hydroxyphenylpropionic acid
METHYL 4-KETOCYCLOHEXANECARBOXYLATE
15-Methylhexadecanoic acid methyl ester, 15-Methylpalmitic acid methyl ester
2-(吡啶基甲基)三苯基溴化膦
替罗非班杂质丁二盐酸盐
POLYDIMETHYLSILOXANE, VINYLDIMETHYLSILOXY TERMINATED
4-Isopropyl-1H-pyrazole hydrochloride
Domperidone impurities1449
(R-type) ginsenoside Rh2
4-Hydroxyphenylpropionic acid
METHYL 4-KETOCYCLOHEXANECARBOXYLATE