4-碘-3-氟吡啶
3-Fluoro-4-iodopyridine
CAS: 22282-75-3
Molecular Formula: C5H3FIN
4-碘-3-氟吡啶 - Names and Identifiers
| Name | 3-Fluoro-4-iodopyridine |
| Synonyms | 4-IODO-3-FLUOROPYRIDINE 4-Iodo-1-fluoropyridine 3-FLUORO-4-IODOPYRIDINE 3-Fluoro-4-iodopyridine Pyridine, 3-fluoro-4-iodo- 2-Fluoro-4-(hydroxymethyl)benzonitrile benzonitrile, 2-fluoro-4-(hydroxymethyl)- |
| CAS | 22282-75-3 |
| InChI | InChI=1/C8H6FNO/c9-8-3-6(5-11)1-2-7(8)4-10/h1-3,11H,5H2 |
4-碘-3-氟吡啶 - Physico-chemical Properties
| Molecular Formula | C5H3FIN |
| Molar Mass | 222.99 |
| Density | 2.046±0.06 g/cm3(Predicted) |
| Melting Point | 85-89 °C |
| Boling Point | 203.1±20.0 °C(Predicted) |
| Flash Point | 127.881°C |
| Solubility | Chloroform, Ethyl Acetate, Methanol |
| Vapor Presure | 0.001mmHg at 25°C |
| Appearance | Crystalline Powder |
| Color | Cream to beige |
| pKa | 1.43±0.18(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.546 |
4-碘-3-氟吡啶 - Risk and Safety
| Risk Codes | 34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3261 8/PG 3 |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
4-碘-3-氟吡啶 - Introduction
3-Fluoro-4-iodopyridine is an organic compound with the chemical formula C5H3FIN. The following is an introduction to its nature, use, preparation and safety information:
Nature:
-Appearance: Colorless to light yellow crystal
-Melting Point: 80-84 ℃
-Boiling point: 204-205 ℃
-Density: 2.11g/cm³
-Solubility: Soluble in ethanol, dimethyl ether and dichloromethane, insoluble in water
Purpose: 3-Fluoro-4-iodopyridine has a wide range of applications in medicinal chemistry and organic synthesis. It can be used as an intermediate for the synthesis of other compounds, such as new drugs, pesticides and dyes. Its special structure makes it have important functions in organic synthesis.
Preparation method: A common preparation method is to synthesize 3-fluororo-4-iodopyridine by reacting pyridine iodide with a fluorinating agent through the substitution reaction of iodine atoms. The specific steps include reacting pyridine iodide with a fluorinating agent (such as trifluoroacetic acid or silver salt of trifluoroacetic acid) in an appropriate solvent to obtain the target compound after the reaction.
Safety information: When using or handling 3-Fluoro-4-iodopyridine, the following safety information should be noted:
-This compound may be toxic to humans, so appropriate personal protective equipment such as gloves, goggles and laboratory coats should be worn during operation.
-Avoid contact with skin and eyes to prevent irritation or injury.
-Operate in a well-ventilated place to prevent inhalation of harmful gases.
-Store the compound in a dry, cool, ventilated place away from fire and oxidizing agents.
Please note that when using and handling any chemical substances, you should follow the correct safety procedures and operate in accordance with relevant regulations and guidelines.
Nature:
-Appearance: Colorless to light yellow crystal
-Melting Point: 80-84 ℃
-Boiling point: 204-205 ℃
-Density: 2.11g/cm³
-Solubility: Soluble in ethanol, dimethyl ether and dichloromethane, insoluble in water
Purpose: 3-Fluoro-4-iodopyridine has a wide range of applications in medicinal chemistry and organic synthesis. It can be used as an intermediate for the synthesis of other compounds, such as new drugs, pesticides and dyes. Its special structure makes it have important functions in organic synthesis.
Preparation method: A common preparation method is to synthesize 3-fluororo-4-iodopyridine by reacting pyridine iodide with a fluorinating agent through the substitution reaction of iodine atoms. The specific steps include reacting pyridine iodide with a fluorinating agent (such as trifluoroacetic acid or silver salt of trifluoroacetic acid) in an appropriate solvent to obtain the target compound after the reaction.
Safety information: When using or handling 3-Fluoro-4-iodopyridine, the following safety information should be noted:
-This compound may be toxic to humans, so appropriate personal protective equipment such as gloves, goggles and laboratory coats should be worn during operation.
-Avoid contact with skin and eyes to prevent irritation or injury.
-Operate in a well-ventilated place to prevent inhalation of harmful gases.
-Store the compound in a dry, cool, ventilated place away from fire and oxidizing agents.
Please note that when using and handling any chemical substances, you should follow the correct safety procedures and operate in accordance with relevant regulations and guidelines.
Last Update：2024-04-09 20:49:11
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QQ: 495145328
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