405939-39-1
tert-butyl N-(5-bromothiazol-2-yl)carbamate
CAS: 405939-39-1
Molecular Formula: C8H11BrN2O2S
405939-39-1 - Names and Identifiers
405939-39-1 - Physico-chemical Properties
| Molecular Formula | C8H11BrN2O2S |
| Molar Mass | 279.15 |
| Density | 1.574±0.06 g/cm3(Predicted) |
| Melting Point | 149 °C |
| Water Solubility | Slightly soluble in water. |
| Appearance | Solid |
| pKa | 4.58±0.70(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.596 |
405939-39-1 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
405939-39-1 - Introduction
tert-butyl N-(5-bromothiazol-2-yl)carbamate is an organic compound with the chemical formula C11H14BrN3O2S. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: White crystalline solid
-Melting point: about 76-78°C
-Solubility: Soluble in common organic solvents such as ethanol, dimethylformamide and methanol
Use:
- tert-butyl N-(5-bromothiazol-2-yl)carbamate is a commonly used organic synthesis intermediate that can be used to synthesize other compounds
-It is usually used in the pharmaceutical field as one of the important intermediates for the synthesis of drugs
Preparation Method:
tert-butyl N-(5-bromothiazol-2-yl)carbamate can be prepared by the following steps:
1. 2-Amino-5-bromothiazole reacts with tert-butyl chloroformate (t-Boc-Cl) under alkaline conditions, and reacts for several hours at room temperature or under heating.
2. Next, the reaction mixture was purified by distillation to obtain the target product.
Safety Information:
- tert-butyl N-(5-bromothiazol-2-yl)carbamate may cause eye and skin irritation. Appropriate protective measures should be taken during use to avoid contact with skin and eyes.
-During handling and storage, care should be taken to prevent contact with oxidants.
-During use and disposal, be sure to follow safe operating procedures and operate under suitable ventilation conditions.
Please note that this only provides general information about the compound. Please strictly follow laboratory safety regulations and chemical specific technical instructions when using and handling.
Nature:
-Appearance: White crystalline solid
-Melting point: about 76-78°C
-Solubility: Soluble in common organic solvents such as ethanol, dimethylformamide and methanol
Use:
- tert-butyl N-(5-bromothiazol-2-yl)carbamate is a commonly used organic synthesis intermediate that can be used to synthesize other compounds
-It is usually used in the pharmaceutical field as one of the important intermediates for the synthesis of drugs
Preparation Method:
tert-butyl N-(5-bromothiazol-2-yl)carbamate can be prepared by the following steps:
1. 2-Amino-5-bromothiazole reacts with tert-butyl chloroformate (t-Boc-Cl) under alkaline conditions, and reacts for several hours at room temperature or under heating.
2. Next, the reaction mixture was purified by distillation to obtain the target product.
Safety Information:
- tert-butyl N-(5-bromothiazol-2-yl)carbamate may cause eye and skin irritation. Appropriate protective measures should be taken during use to avoid contact with skin and eyes.
-During handling and storage, care should be taken to prevent contact with oxidants.
-During use and disposal, be sure to follow safe operating procedures and operate under suitable ventilation conditions.
Please note that this only provides general information about the compound. Please strictly follow laboratory safety regulations and chemical specific technical instructions when using and handling.
Last Update：2024-04-09 15:17:57
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CAS: 405939-39-1
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