40769-69-5

40769-69-5 - Names and Identifiers

Name	2,5-Diamino-4,6-dihydroxy-pyrimidine
Synonyms	AKOS 91522 2,5-DIAMINOPYRIMIDINE-4,6-DIOL 2,5-Diamino-4,6-pyrimidinediol 2,5-diamino-4,6-dihydroxypyrimidine 2,5-DIAMINO-4,6-DIHYDROXYPYRIMIDINE 2,5-Diamino-4,6-dihydroxy-pyrimidine 2,5-diamino-6-hydroxypyrimidin-4(3H)-one 2,5-Diamino-6-hydroxypyrimidine-4(3H)-one 2,5-Diamino-4,6-dihydroxypyrimidine HCl monohydrate 2,5-Diamino-4,6-dihydroxy pyrimidine HCI. (DADHP HCl) 2,5-diamino-6-hydroxypyrimidin-4(3H)-one hydrochloride 2,5-DIAMINO-4,6-DIHYDROXYPYRIMIDINE HYDROCHLORIDE HYDRATE
CAS	40769-69-5
InChI	InChI=1/C4H6N4O2/c5-1-2(9)7-4(6)8-3(1)10/h5H2,(H4,6,7,8,9,10)

40769-69-5 - Physico-chemical Properties

Molecular Formula	C4H6N4O2
Molar Mass	142.12
Density	2.15±0.1 g/cm3(Predicted)
Melting Point	260 C
Boling Point	524.2°C at 760 mmHg
Flash Point	270.9°C
Vapor Presure	1.31E-11mmHg at 25°C
pKa	8.52±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.877

40769-69-5 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.

40769-69-5 - Reference Information

introduction

2,5-diamino-4, 6-dihydroxypyridine is an organic chemical intermediate, which can be used to synthesize 2-
amino -4, 6-dichloro-5-formylaminopyrimidine, and is widely used in the synthesis of AIDS prevention and treatment drugs, there are dozens of varieties of AIDS drugs synthesized with it. The new AIDS drugs manufactured have unique functions and are a promising drug and synthetic drug intermediates. AIDS is a clinical syndrome in which human immunodeficiency virus (HIV) infection leads to defects in human defense functions (especially cell-mediated immune function defects), and is prone to opportunistic infections and tumors.

preparation

diethyl malonate (32g,0.2mol), guanidine hydrochloride (9.6g,0.1mol), sodium ethoxide (27.2g,0.4mol) and ethanol 150mL were heated and refluxed. after the reaction, the obtained solid and sodium nitrite (13.8g,0.2mol) were heated and refluxed in 200mL of water, the solution of ethanol 170mL and acetic acid 16mL was reacted at 25 ℃ for 24 hours. After the reaction, the solid obtained was refluxed in the presence of sodium dithionite (43.5g,0.25mol) and water 200mL for 8 hours to obtain 2,5-diamino-4, 6-dihydroxypyrimidine with a yield of 48%.

Last Update：2024-04-09 21:11:58