40807-61-2
4-hydroxy-4-phenylpiperidine
CAS: 40807-61-2
Molecular Formula: C11H15NO
40807-61-2 - Names and Identifiers
| Name | 4-hydroxy-4-phenylpiperidine |
| Synonyms | NSC 71658 4-phenylpiperidin-4-ol LABOTEST-BB LT00233127 Traxoprodil Impurity 3 4-HYDROXY-4-PHENYLPIPERIDINE 4-hydroxy-4-phenylpiperidine 4-Hydroxy-4-phenylpiperadine 4-(4-Phenyl)-4-Hydroxy Piperidine (2-methyl-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)-(1-piperidinyl)methanone |
| CAS | 40807-61-2 |
| EINECS | 255-089-0 |
| InChI | InChI=1/C11H15NO/c13-11(6-8-12-9-7-11)10-4-2-1-3-5-10/h1-5,12-13H,6-9H2 |
| InChIKey | KQKFQBTWXOGINC-UHFFFAOYSA-N |
40807-61-2 - Physico-chemical Properties
| Molecular Formula | C11H15NO |
| Molar Mass | 177.24 |
| Density | 1.093 |
| Melting Point | 157-161°C(lit.) |
| Boling Point | 317.9°C at 760 mmHg |
| Flash Point | 137.2°C |
| Vapor Presure | 0.000157mmHg at 25°C |
| Appearance | Solid |
| Color | Pale brown |
| BRN | 141577 |
| Storage Condition | 2-8°C(protect from light) |
| Refractive Index | 1.559 |
| MDL | MFCD00006000 |
40807-61-2 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
40807-61-2 - Reference Information
| Use | 4-phenyl-4-hydroxypiperidine is a pharmaceutical intermediate, which can be made of bromobenzene and Boc-4-piperidone or Cbz-4-piperidone is obtained through a two-step reaction as a raw material. |
| Preparation method | Step A: Add a solution of bromobenzene (1.0 equivalents) in n-BuLi(1.05 equivalents) in THF dropwise to a solution of bromobenzene (equivalents) in anhydrous THF at -78°C. After addition, the mixture was stirred at -78°C for about 0.5 hours. Then, the solution of Boc-4-piperidone in THF was added dropwise by syringe at -78°C. After adding, the resulting mixture was stirred at -78°C at N2 for 2h, and then heated to r.t. The reaction mixture was quenched with a saturated NH4Cl solution, and the resulting mixture was extracted with EtOAc(50mL,30mL). The combined organic phase was washed with brine, dried with anhydrous Na2SO4, and concentrated under vacuum. The residue was purified by column chromatography (PE/EtOAc) to give the compound 1-BC-4-phenyl-4-hydroxypiperidine. Step B: Add a solution of HCl(3 equivalents) in dioxane to a solution of compound 1-BOC-4-phenyl-4-hydroxypiperidine (1 equivalent) in dioxane, and stir the reaction mixture at room temperature for about 2 hours. At this time, LCMS detects that there is no s.m. Concentrate the reaction mixture to obtain the desired product 4-phenyl-4-hydroxypiperidine. |
Last Update：2024-04-09 21:01:54
Supplier List
Featured ProductsSpot supply
Product Name: 4-Hydroxy-4-phenylpiperidine Visit Supplier Webpage Request for quotationCAS: 40807-61-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 4-hydroxy-4-phenylpiperidine Visit Supplier Webpage Request for quotationCAS: 40807-61-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: 4-Phenyl-4-Piperidinol Visit Supplier Webpage Request for quotation
CAS: 40807-61-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 40807-61-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: 4-Hydroxy-4-phenylpiperidine Visit Supplier Webpage Request for quotationCAS: 40807-61-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 4-hydroxy-4-phenylpiperidine Visit Supplier Webpage Request for quotationCAS: 40807-61-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: 4-Phenyl-4-Piperidinol Visit Supplier Webpage Request for quotation
CAS: 40807-61-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 40807-61-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
40807-61-2
Tridecylbenzene
HS1371
56219-06-8
7727-43-7
66-25-1
5-ethylthiophene-2-carbaldehyde
BRL-54443
14606-42-9
SNJ-1945
Tridecylbenzene
HS1371
56219-06-8
7727-43-7
66-25-1
5-ethylthiophene-2-carbaldehyde
BRL-54443
14606-42-9
SNJ-1945