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4085-31-8

Piperaquinoline

CAS: 4085-31-8

Molecular Formula: C29H32Cl2N6.H3PO4

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4085-31-8 - Names and Identifiers

Name Piperaquinoline
Synonyms Piperaquinoline
piperaquinoline
PIRERAQUINEPHOSPHATE
PiperaquinephosphateCP2000
4,4'-(trimethylenedi-4,1-piperazinediyl)bis(7-chloro-quinoline)
4,4'-(1,3-Propanediydi-4,1-piper-azinediyl)bis[7-chloroquinoline]
1,3-bis[1-(7-chloro-4-quinolyl)-4'-piperazinyl]propanetetraphosphatetetrahydrate
CAS 4085-31-8
EINECS 202-303-5

4085-31-8 - Physico-chemical Properties

Molecular FormulaC29H32Cl2N6.H3PO4
Molar Mass633.51
Density1.292±0.06 g/cm3(Predicted)
Melting Point198-200 °C
Boling Point721.1±60.0 °C(Predicted)
Storage Condition2-8°C
Physical and Chemical PropertiesChemical properties of white crystalline powder is not, slightly dissolved in water.
UseUse: anti-malaria drugs

4085-31-8 - Determination of piperaquine phosphate in human plasma by high performance liquid chromatography

from titanium academic

Author:

Chang-Hui Liu Yellow days , Hong xin , ear Qing , Wang Ningsheng

Abstract:

Objective: to establish a method for determination of piperaquine phosphate in human plasma by high performance liquid chromatography with ultraviolet detection. Methods: plasma samples were basified with 1 mol · L ~(-1) sodium hydroxide solution, extracted with diethyl ether, absorbed organic phase, dried by N_2 gas flow, and reconstituted with mobile phase. Alltima C_(18) column (4.6 × 150, 5 μm), mobile phase was acetonitrile-0.1%(w/v) trichloroacetic acid-phosphoric acid (25:75:0.035,v/v/v), the flow rate was 0.4 mL · min ~(-1), the column temperature was room temperature, the detection wavelength was 345 nm, and chloroquine phosphate was used as internal standard. Results: piperaquine phosphate, internal standard and endogenous impurities were well separated. The linear range was 0.02~1.0 μg · mL ~(-1)(r = 0.9993), the lower limit of quantitation was 0.01 μg · mL ~(-1), the intra-day and inter-day RSD was less than 12%, the extraction recovery was 69.3% ~ 76.3%, and the method recovery was 93.4% ~ 106.5%. Conclusion: The method is accurate, stable, sensitive and suitable for the Study of pharmacokinetics and bioavailability of piperaquine phosphate.

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Key words:

piperaquine phosphate plasma concentration HPLC

DOI:

CNKI:SUN:YWFX.0.2007-01-017

cited:

7

year:

2007

Last Update：2024-01-02 23:10:35

4085-31-8 - Study on determination of related substances of piperaquine phosphate

from VIP Journal Professional Edition

Author:

Zhang kushong , Jiang Sheng , Mao Qing

Abstract:

Objective to establish an HPLC method for the determination of related substances in piperaquine phosphate and to investigate the stability of piperaquine phosphate against light. Methods an Agilent C18 column was used, with 0.04mol.L-1 potassium dihydrogen phosphate-acetonitrile-triethylamine (90:10:0.2, adjusted to pH 2.5 with phosphoric acid) as mobile phase, flow rate: 0.5mL.min-1, detection wavelength: 230nm, column temperature: 25 ℃. Results the content of related substances of piperaquine phosphate was 0.21% ~ 0.39%, which was significantly increased after 10 days of strong light irradiation. Conclusion The method is accurate, reliable, simple and rapid, and suitable for the quality control of piperaquine phosphate.

Key words:

piperaquine phosphate Related substances HPLC

DOI:

10.3969/j.issn.1002-7777.2007.11.009

cited:

11

year:

2009

Last Update：2023-08-16 22:09:08
4085-31-8
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Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Piperaquinoline Request for quotation
CAS: 4085-31-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Piperaquine phosphate Visit Supplier Webpage Request for quotation
CAS: 4085-31-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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4085-31-8
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