41354-29-4
Cyproheptadine hydrochloride
CAS: 41354-29-4
Molecular Formula: C21H24ClNO
41354-29-4 - Names and Identifiers
41354-29-4 - Physico-chemical Properties
| Molecular Formula | C21H24ClNO |
| Molar Mass | 341.88 |
| Melting Point | 165°C (dec.)(lit.) |
| Boling Point | 440.1 °C at 760 mmHg |
| Solubility | ethanol: soluble;methanol: soluble |
| Appearance | solid(white to slightly yellow) |
| Color | white to slightly yellow |
| Maximum wavelength(λmax) | ['285nm(0.05mol/L H2SO4)(lit.)'] |
| Merck | 14,2773 |
| Storage Condition | Inert atmosphere,Room Temperature |
| MDL | MFCD00150043 |
41354-29-4 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | TM7050000 |
| HS Code | 29333990 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 orally in mice: 74.2 mg/kg (Loux) |
41354-29-4 - Reference Information
| Introduction | cyproheptadine hydrochloride, also known as diphenylcycloheptadine, metapantin, ethylphenylcycloheptadine, A hexahydropyridine antihistamine that competes with histamine released from tissues for H1 receptors on effector cells, thereby preventing the onset of allergic reactions, relieve histamine induced spasmolysis and hyperemia, the goods have a strong H1 receptor antagonism, antihistamine effect than chlorpheniramine, promethazine strong. Mild to moderate anti-serotonin and anti-cholinergic effects. In addition, there is the role of stimulating appetite, after a certain period of time visible weight gain. |
| indications | cyproheptadine hydrochloride hemihydrate is mainly used for acute and chronic urticaria (especially cold urticaria has good effect), papular urticaria, angioedema, allergic eczema, contact dermatitis, food allergy, drug allergy, allergic rhinitis, hay fever, allergic conjunctivitis, insect sting allergy and migraine. It has a certain therapeutic effect on bronchial asthma. Can be used for Cushing's syndrome, acromegaly adjuvant therapy. It can also be used as an appetite enhancer for anorexia nervosa. Treatment of acanthosis nigricans and prevention of necrotizing pyoderma have been reported. |
| dosage | oral dosage form (1) allergic diseases: adults, 2~4mg once, 2-3 times a day. (2) hypercortisolism, suitable for the treatment of bilateral adrenal hyperplasia, which can inhibit the release of corticotropin-releasing hormone (CRH) from hypothalamus and pituitary adrenocorticotropic hormone (ACTH) the secretion, thereby reducing the level of plasma ACTH and cortisol; Adults start 8mg a day, can be gradually increased to 24mg a day; The commonly used dose is 12~24mg a day, divided into doses, need long-term application; in the case of insufficient cortical function after bilateral total or Subtotal adrenalectomy, on the one hand, adding corticosteroids, on the other hand, taking cyproheptadine can reduce the chance of pituitary tumor. |
| drug interaction | 1. It should not be combined with ethanol, which can increase its sedative effect. 2. Should not be combined with the central nervous system inhibitory drugs. 3. Combined with phenothiazine drugs (such as chlorpromazine, etc.) can increase the risk of ventricular arrhythmia, and in severe cases can cause torsade de pointes. 4. If concomitant use with other drugs may cause drug interaction, for details, please contact Counseling physician or pharmacist. |
| Use | for the treatment of urticaria, pruritus, allergic rhinitis. new anticoagulant and antiallergic drugs. Can be used for urticaria, eczema, allergic and contact dermatitis, skin itching and other allergic reactions. Urticaria, eczema, allergic and contact dermatitis, skin itching, rhinitis, migraine, bronchial asthma, etc. It can also be used for Cushing's disease and acromegaly. 5-HT2/5-HT1C serotonin receptor antagonist; H1 histamine receptor antagonist; Antipruritic agent |
Last Update：2024-04-09 15:16:51
Supplier List
Multiple SpecificationsSpot supply
Product Name: Cyproheptadine hydrochloride sesquihydrate Visit Supplier Webpage Request for quotationCAS: 41354-29-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Cyproheptadine hydrochloride sesquihydrate Request for quotation
CAS: 41354-29-4
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380
Wechat: 15387090420
CAS: 41354-29-4
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380
Wechat: 15387090420
Multiple SpecificationsSpot supply
Product Name: Cyproheptadine hydrochloride sesquihydrate Visit Supplier Webpage Request for quotationCAS: 41354-29-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Cyproheptadine hydrochloride sesquihydrate Request for quotation
CAS: 41354-29-4
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380
Wechat: 15387090420
CAS: 41354-29-4
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380
Wechat: 15387090420
View History