41605-31-6
4-[3-(Trifluoromethyl)phenoxy]aniline
CAS: 41605-31-6
Molecular Formula: C13H10F3NO
41605-31-6 - Names and Identifiers
| Name | 4-[3-(Trifluoromethyl)phenoxy]aniline |
| Synonyms | AKOS B033080 4-(3-TRIFLUOROMETHYLPHENOXY)ANILINE 4-[3-(Trifluoromethyl)phenoxy]aniline Benzenamine, 4-[3-(trifluoromethyl)phenoxy]- |
| CAS | 41605-31-6 |
| InChI | InChI=1/C13H10F3NO/c14-13(15,16)9-2-1-3-12(8-9)18-11-6-4-10(17)5-7-11/h1-8H,17H2 |
41605-31-6 - Physico-chemical Properties
| Molecular Formula | C13H10F3NO |
| Molar Mass | 253.22 |
| Density | 1.293g/cm3 |
| Boling Point | 140°C/5mm |
| Flash Point | 148.5°C |
| Vapor Presure | 0.00029mmHg at 25°C |
| Refractive Index | 1.545 |
41605-31-6 - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
41605-31-6 - Introduction
4-[3-(Trifluoromethyl)phenoxy]aniline is an organic compound whose chemical formula is C13H10F3NO. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: White solid
-Solubility: Soluble in some organic solvents, such as ethanol and dimethylformamide
-Melting point: about 58-62°C
-Molecular weight: 267.22g/mol
Use:
- 4-[3-(Trifluoromethyl)phenoxy]aniline is commonly used as an intermediate in pharmaceuticals or pesticides. It can be used to synthesize compounds with different biological activities, such as drugs and pesticides.
-In organic synthesis, it can also be used as a substitution reaction reagent for aromatic compounds.
Preparation Method:
- 4-[3-(Trifluoromethyl)phenoxy] One method of synthesis of aniline is through the substitution reaction of aniline. First, trifluoroformic acid is added to aniline under basic conditions to produce the corresponding trifluoromethylaniline. Then, 3-trifluoromethylaniline is subjected to an oxidative coupling reaction with phenol to form 4-[3-(Trifluoromethyl)phenoxy]aniline under basic conditions.
Safety Information:
-When using or handling 4-[3-(Trifluoromethyl)phenoxy]aniline, necessary laboratory safety measures should be taken, such as wearing gloves, laboratory clothing and eye protection.
-The compound may be irritating to the eyes and skin and can cause allergic reactions.
-Avoid inhaling its dust or vapors. In case of overdose, immediately go to an air circulation area for fresh air and seek medical help.
-When storing and handling this compound, follow the relevant safety procedures.
Nature:
-Appearance: White solid
-Solubility: Soluble in some organic solvents, such as ethanol and dimethylformamide
-Melting point: about 58-62°C
-Molecular weight: 267.22g/mol
Use:
- 4-[3-(Trifluoromethyl)phenoxy]aniline is commonly used as an intermediate in pharmaceuticals or pesticides. It can be used to synthesize compounds with different biological activities, such as drugs and pesticides.
-In organic synthesis, it can also be used as a substitution reaction reagent for aromatic compounds.
Preparation Method:
- 4-[3-(Trifluoromethyl)phenoxy] One method of synthesis of aniline is through the substitution reaction of aniline. First, trifluoroformic acid is added to aniline under basic conditions to produce the corresponding trifluoromethylaniline. Then, 3-trifluoromethylaniline is subjected to an oxidative coupling reaction with phenol to form 4-[3-(Trifluoromethyl)phenoxy]aniline under basic conditions.
Safety Information:
-When using or handling 4-[3-(Trifluoromethyl)phenoxy]aniline, necessary laboratory safety measures should be taken, such as wearing gloves, laboratory clothing and eye protection.
-The compound may be irritating to the eyes and skin and can cause allergic reactions.
-Avoid inhaling its dust or vapors. In case of overdose, immediately go to an air circulation area for fresh air and seek medical help.
-When storing and handling this compound, follow the relevant safety procedures.
Last Update：2024-04-09 21:01:54
