4168-17-6
Catharanthine hemitartrate
CAS: 4168-17-6
Molecular Formula: C25H30N2O8
4168-17-6 - Names and Identifiers
4168-17-6 - Physico-chemical Properties
| Molecular Formula | C25H30N2O8 |
| Molar Mass | 486.51 |
| Melting Point | 145-1470C |
| Solubility | Soluble in water, insoluble in organic solvents such as petroleum ether and chloroform. |
| Appearance | White crystal |
| Color | White to Pale Beige |
| Storage Condition | Inert atmosphere,2-8°C |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from the Vinca. |
4168-17-6 - Reference Information
| application | vinblastine tartrate is the tartrate of vinblastine, vinblastine (English name Catharanthine?) it is a kind of periwinkle alkaloid. Animal experiments show that it has antihypertensive effect. It is one of the important starting materials for the synthesis of anti-tumor drugs vinorelbine tartrate, vinblastine sulfate and vincristine, which are widely used in clinic. It has a wide range of application value. |
| preparation | a preparation method of vinblastine tartrate. the method uses the whole plant of fresh vinblastine as the starting material to increase the content of vinblastine. crude vinblastine with a purity of about 78% can be obtained through extraction and pH extraction separation and purification, more than 99% high-purity vinblastine tartrate with easy preservation can be directly obtained by salt formation and recrystallization. The specific technical scheme is as follows: (1) take the whole plant of fresh Catharanthus roseus, soak it with sodium chloride aqueous solution, then take it out and freeze it directly into cold air at -15 ~-25 ℃ with a flow rate of 5-8m/s, freeze dry, and crush the whole plant of Catharanthus roseus after freeze drying; (2) add the whole plant powder of Catharanthus roseus in step (1) to water and adjust the pH to 1.3-1.6, ultrasonic soak for 2-3h, filter to take the filtrate, adjust the pH of the filtrate to 8-9, and then spray it from the top of the extraction tank in the form of spray, and spray the extractant from the lower part of the extraction tank in the form of spray At the same time, the extraction is completed to collect the organic phase; the extractant is a mixture of n-bromopropane and ethanol; (3) The organic phase is reduced pressure to remove the solvent, and the residue is completely dissolved with anhydrous ethanol, the ethanol solution with sulfuric acid is added to adjust the pH to 3.8-4.1, let stand and separate, and take the filtrate; (4) evaporate the filtrate in step (3) under reduced pressure, dissolve the residue with water, adjust the pH to 1.5-2.5, stir until the solution is clarified, then extract with the mixed liquid of dichloromethane and ethyl acetate, take the water phase, and adjust the pH to 4.5-4.8 in the water phase, then the mixture of toluene and petroleum ether is extracted, and the obtained organic phase is evaporated to dry under reduced pressure to obtain crude vinblastine; (5) The crude vinblastine is dissolved with methanol, and then the methanol solution of tartaric acid is added to it, ultrasonic reaction, crystallization, and vinblastine tartrate is obtained; (6) Vinblastine tartrate is added to N,N-dimethylformamide, heat until completely soluble, then add the mixture of methanol and ethyl acetate, stir evenly and recrystallize, and the obtained crystal is pure vinblastine tartrate. |
| biological activity | Catharanthine Tartrate are alkaloids in Catharanthus roseus, which inhibit voltage-gated L-type calcium channels (voltage-operated L-type Ca2 + channel) and have anti-tumor and antihypertensive activities. |
| use | vinblastine tartrate has hypoglycemic and anti-tumor effects. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: It has a good effect on Hodgkin's disease and chorionic nerve epithelial cancer, and has a certain effect on acute leukemia, breast cancer, ovarian cancer, testicular cancer, head and neck cancer, oropharyngeal cancer, and monocytic leukemia. |
Last Update：2024-04-09 20:45:29
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Product Name: Catharanthine hemitartrate Visit Supplier Webpage Request for quotationCAS: 4168-17-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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