41743-73-1
Irisflorentin
CAS: 41743-73-1
Molecular Formula: C20H18O8
41743-73-1 - Names and Identifiers
| Name | Irisflorentin |
| Synonyms | IRISFLORENTIN Irisflorentin Irisflorentin 41743-73-1 3',4',5,5'-Tetramethoxy-6,7-(epoxymethanoxy)isoflavone 9-Methoxy-7-(3,4,5-trimethoxyphenyl)-[1,3]dioxolo[4,5-g]chromen-8-one 9-methoxy-7-(3,4,5-trimethoxyphenyl)-8H-[1,3]dioxolo[4,5-g]chromen-8-one 9-Methoxy-7-(3,4,5-trimethoxyphenyl)-8H-1,3-dioxolo[4,5-g][1]benzopyran-8-one 7-(3,4,5-Trimethoxyphenyl)-9-methoxy-8H-1,3-dioxolo[4,5-g][1]benzopyran-8-one |
| CAS | 41743-73-1 |
| InChI | InChI=1/C20H18O8/c1-22-13-5-10(6-14(23-2)18(13)24-3)11-8-26-12-7-15-19(28-9-27-15)20(25-4)16(12)17(11)21/h5-8H,9H2,1-4H3 |
41743-73-1 - Physico-chemical Properties
| Molecular Formula | C20H18O8 |
| Molar Mass | 386.35 |
| Density | 1.348±0.06 g/cm3(Predicted) |
| Melting Point | 165-167 °C |
| Boling Point | 569.1±50.0 °C(Predicted) |
| Flash Point | 250.5°C |
| Solubility | DMSO : 50 mg/mL (129.42 mM; Need ultrasonic) |
| Vapor Presure | 5.75E-13mmHg at 25°C |
| Appearance | Colorless needle crystal |
| Color | White to Almost white |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.593 |
| MDL | MFCD02183467 |
| Physical and Chemical Properties | Roots and rhizomes from Belamcanda |
41743-73-1 - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29329990 |
41743-73-1 - Reference
| Reference Show more | 1. Li forest, Liu Chunming, Li Synan, etc. Isolation and mass spectrometric analysis of lactate dehydrogenase inhibitors in Belamcanda chinensis [J]. Natural product research and development, 2017, 04(v.29):57-62. 2. Li Rong. Comparative analysis on the quality of chuanshegan and Belamcanda [J]. Strait pharmacy, 2019, v.31;No.237(10):65-68. 3. Valkω, Kl · ra. "Application of high-performance liquid chromatography based measurements of obesity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https:// doi.org/10.1016/j.chroma.2003.10.084 4. Valkω, Kl · ra. "Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https://doi.org/10.1016/j.chroma.2003.10.084 5. [IF=4.411] Jifeng Gu et al."Application of High-Performance Liquid Chromatography Coupled with Linear Ion Trap Quadrupole Orbitrap Mass Spectrometry for Qualitative and Quantitative Assessment of Shejin-Liyan Granule Supplements."Molecules. 2018 Apr;23(4):884 |
41743-73-1 - Reference Information
| overview | isoflavones in ejaculate have anti-inflammatory, antiviral, antibacterial and free radical elimination effects. Iridin subwild is one of the effective ingredients in ejaculation. With the decrease of wild resources of shoot dry, in order to protect resources, more and more researches have been made on the biology, introduction and cultivation of shoot dry in recent years. In this paper, HPLC method was used to determine the content of sub-wild irisin in cultivated shoot-dried. According to the measurement results, the quality evaluation is carried out. Irisflorentin,IFR) is the main effective ingredient in Chinese herbal medicine shot dried, which has many pharmacological effects such as anti-inflammatory, sterilization, heat-clearing and detoxification, antioxidant, etc. [3]. |
| Plant source | Iridaceae (Iridaceae) Belamcanda chinensis L. Rhizome Iris dichotoma Pall. Rhizome (yield: 0.002%) Iris florentina L. Rhizome Iris germanica L. Rhizome of Iris germany Iris hookeriana Foster Rhizome of Iris Hooker (yield: 0.005%) Iris kumaonensis Dykes Iris of Tangier Iris tingitana Boiss. & Reut. Bulbs |
| determination of content | high performance liquid chromatography was used, and the chromatographic column was TSK ge1 ODS 80 TS250 mm × 4. 6mm; The mobile phase is methanol-phosphoric acid aqueous solution (pH = 3): 53%: 47%; The flow rate is 1 ml/min; The detection wavelength is 266 nm; The column temperature is 35 ℃. Results The linear relationship between the peak area and the peak area of sub-wild iris flavin in the range of 0. 0118~0. 118μ g (r = 0. 999 9). The average recovery rate was 99. 84%,RSD was 2. 059%, and the content of sub-wild iris flavin was 0. 1252%. Fig. 1 HPLC chromatogram of irisone reference substance |
| The interaction between sub-wild iristhflavin and bovine serum albumin | The effect of metal ions Fe3, Ca2, Cu2 or Mn2 on the interaction between sub-wild iristhflavin (IFR) and bovine serum albumin (BSA) was studied by fluorescence spectrophotometry. The experimental results show that when there are no metal ions, the fluorescence quenching process of IFR on BSA is dynamic quenching, the apparent binding constant KA value of the binding process is 104~105 orders of magnitude, and the number of binding sites n is approximately equal to 1. From the thermodynamic parameters, it is concluded that the binding process of IFR and BSA is a spontaneous process of increasing entropy and decreasing Gibbs free energy, and the intermolecular interaction force is mainly hydrophobic force. In the presence of Fe3 or Ca2, the fluorescence quenching type of BSA by IFR changes from dynamic quenching to static quenching, and the type of force also changes from hydrophobic force to hydrogen bond and van der Waals force or electrostatic gravity. In the presence of Cu2 or Mn2, the fluorescence quenching type and intermolecular force type of BSA by IFR did not change. The participation of four kinds of metal ions makes the apparent binding constant of IFR and BSA obviously change, but the number of binding sites remains at about 1. |
| References | [1] Editor-in-Chief Chen Huifang. Dictionary of Plant Active Ingredients, Volume 3. Beijing: China Medical Science and Technology Press. 2001. Page 640-641. [2] Chen Yinhua, Meng Junhua, Hou Junjie, Liu Hegang. Determination of Iridin in Cultivated Shegan by High Performance Liquid Chromatography [J]. Shi Zhen Chinese Medicine, 2007,(06):1391-1392. [3] Wang Anping, Zhang Guowen, Pan Junhui, gong Yi. Effect of metal ions on the interaction between sub-wild iristhoin and bovine serum albumin [J]. Journal of Analytical Sciences, 2008,(04):389-393. |
| use | used for content determination/identification/pharmacological experiments, etc. Pharmacological effects: It has obvious anti-inflammatory, antipyretic, phlegm, anti-microbial and other pharmacological effects. The IC50 for cAMP phosphodiesterase was 4 μM. |
Last Update：2024-04-09 21:54:55
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Product Name: Irisflorentin Visit Supplier Webpage Request for quotationCAS: 41743-73-1
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