4219-52-7
NSC745885
CAS: 4219-52-7
Molecular Formula: C14H6N2O2S
4219-52-7 - Names and Identifiers
4219-52-7 - Physico-chemical Properties
| Molecular Formula | C14H6N2O2S |
| Molar Mass | 266.27 |
4219-52-7 - References
| biological activity | NSC745885 is a potent anti-tumor agent, selective toxicity to a variety of cancer cell lines, but no toxicity to normal cells. NSC745885 is a potent downregulator of EZH2 via the proteasome degradation pathway. NSC745885 offers the possibility for the study of advanced bladder cancer and oral squamous cell carcinoma. |
| Cell Line: | SAS cells is obtained from a poorly differentiated human squamous cell carcinoma SAS cells is obtained from a poorly differentiated human squamous cell carcinoma SAS cells is obtained from a poorly differentiated human squamous cell carcinoma |
| Concentration: | 0.5 μM, 1 μM, 1.5 μM, 2 μM, 4 μM 0.5 μM, 1 μM, 1.5 μM, 2 μM, 4 μM 0.5 μM, 1 μM, 1.5 μM, 2 μM |
| Incubation Time: | 24, 48, or 72 hours 24 hours 24 or 48 hours |
| Result: | Decreases SAS cells growth as a time and dose-dependent manner. Decreases SAS cells growth as a time and dose-dependent manner. Increased cleaved caspase-3 expression and decreased XIAP expression. Inhibited engrafted tumors growth in vivo. |
| Animal Model: | Eight-week-old NOD/SCID (NOD.CB17 Prkdc scid /J) mice |
| Dosage: | 2 mg/kg |
| Administration: | Intraperitoneal injection; 2 mg/kg; once daily; 10 days |
Last Update：2024-04-09 20:49:11
