42509-80-8
Isazophos
CAS: 42509-80-8
Molecular Formula: C9H17ClN3O3PS
42509-80-8 - Names and Identifiers
42509-80-8 - Physico-chemical Properties
| Molecular Formula | C9H17ClN3O3PS |
| Molar Mass | 313.74 |
| Density | 1.22 g/cm3 (20℃) |
| Melting Point | <25℃ |
| Boling Point | bp0.001 100°; bp760 170° |
| Water Solubility | 168 mg l-1 (20 °C) |
| Vapor Presure | 7.45 x 10-3 Pa (20 °C) |
| Appearance | Morphological liquid |
| pKa | -1.47±0.10(Predicted) |
| Storage Condition | 0-6°C |
| Refractive Index | nD20 1.4867 |
| Physical and Chemical Properties | The pure chemical product is a yellow liquid. B. p. 100 ℃/0.1333Pa, relative density 1.22 (20 ℃), n20D1.4867, vapor pressure 1.76 × 10-3Pa (20 ℃). It is soluble in organic solvents such as methanol and trichlorotetrane, and the solubility in water is only 150mg/L. Stable in neutral and acidic media, easy to decompose under alkaline conditions. |
| Use | Use of insecticides, nematicides, contact kill, stomach poison and the role of absorption. Used for corn, cotton, rice, sugar beet, grass and vegetables, the control of long wax, nematodes, rice stem, etc. It can be used for foliar spraying, and can be used for soil or seed treatment, and the dose per hectare is 0.5 ~ 2kg. Should not be used on the potato, in order to prevent damage. |
42509-80-8 - Risk and Safety
| Risk Codes | R24/25 - R26 - Very Toxic by inhalation R43 - May cause sensitization by skin contact R48/20 - R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37 - Wear suitable protective clothing and gloves. S38 - In case of insufficient ventilation, wear suitable respiratory equipment. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S59 - Refer to manufacturer / supplier for information on recovery / recycling. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | 3018 |
| WGK Germany | 3 |
| RTECS | TE7760000 |
| HS Code | 29339900 |
| Hazard Class | 6.1(a) |
| Packing Group | II |
| Toxicity | LD50 in rats (mg/kg): 60 orally; 250-700 dermally (Dawes) |
42509-80-8 - Nature
| BRN | 8145294 |
| EPA chemical information | Isazofos (42509-80-8) |
Last Update：2024-04-10 22:29:15
42509-80-8 - Uses and synthesis methods
Toxicity
the acute oral LD50 of rats is 40~60 mg/kg, the acute percutaneous LD50 is 250~700 mg/kg, and the acute inhalation LD50 is 250mg/L (4h). It has a stimulating effect on the skin. Animal experiments have no teratogenic, carcinogenic and mutagenic effects, and reproduction tests have no abnormalities. Highly toxic to birds, fish and bees.
production method
isocyanate method
preparation of chlorocarbonyl dichloride tetracarbamoyl chloride reacts with carbon tetrachloride to remove hydrogen chloride to generate methyl isocyanate, then chlorine gas is passed under light, chlorination temperature is 35 ℃, chlorine content is 15-18g per hour, reaction time is more than 10h, chlorinated liquid is distilled at atmospheric pressure, and fractions at 115-118 ℃ are collected with 70% yield.
preparation of isopropylhydrazine, bromoisopropane is dropwise added to 85% hydrazine hydrate at a dropwise temperature of less than 35 ℃, about 2~3h after the dropwise addition, the temperature is raised to 55~60 ℃, and the reaction is 3h. Cooling, ether extraction, 65% yield. Neutralized by hydrochloric acid, concentrated and crystallized to obtain isopropylhydrazine hydrochloride.
preparation of isoxazole alcohol, reduce the temperature of isopropyl hydrazine or isopropyl hydrazine hydrochloride and solvent to below 20 ℃, add equal molar chlorocarbonyl dichloride dropwise, temperature 20 ℃, time 20min, and finish dropwise. Stirring at room temperature for 1h, heating and reflux for 3h, cooling, filtering, concentration of filtrate under reduced pressure, recrystallization of residue to obtain white solid, m.p. 98~100 ℃, yield 45%.
synthesis of chlorazophos isoxazole alcohol, anhydrous potassium carbonate and solvent are heated and refluxed for 2 hours, cooled to room temperature, equimolar O,O-diethyl thiophosphoryl chloride is added dropwise, heated and refluxed for 3 hours after dripping, cooled, filtered, and dissolved under reduced pressure to obtain yellow transparent liquid, n20D1.4868, yield> 90%.
Last Update：2024-04-10 22:29:15
42509-80-8 - Security information
| toxic substance data | 42509-80-8(Hazardous Substances Data) |
Last Update：2024-04-10 22:29:15
Supplier List
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Multiple Specifications
Product Name: Isazophos Visit Supplier Webpage Request for quotationCAS: 42509-80-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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