42521-09-5

42521-09-5 - Names and Identifiers

Name	Methyl 2,6-Dichloroisonicotinate
Synonyms	Methyl 2,6-Dichloroisonicotinate METHYL 2,6-DICHLOROISONICOTINATE Methyl 2,6-dichloro-4-pyridinecarboxylate 2,6-Dichloro-isonicotinic acid methyl ester METHYL 2,6-DICHLORO-4-PYRIDINE-CARBOXYLIC ACID 2,6-CHLORO-4-PYRIDINECARBOXYLIC ACID METHYL ESTER 2,6-Dichloro-4-pyridinecarboxylic acid methyl ester 2,6-Dichloropyridine-4-carboxylic acid methyl ester 4-PYRIDINECARBOXYLIC ACID, 2,6-DICHLORO-, METHYL ESTER
CAS	42521-09-5
EINECS	255-868-5
InChIKey	XSKGHSUHOYEBTK-UHFFFAOYSA-N

42521-09-5 - Physico-chemical Properties

Molecular Formula	C7H5Cl2NO2
Molar Mass	206.03
Density	1.426
Melting Point	82 °C
Boling Point	298℃
Flash Point	134℃
Solubility	Sparingly Soluble (0.13 g/L) (25°C)
pKa	-4.32±0.10(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature

42521-09-5 - Risk and Safety

Hazard Symbols	Xi - Irritant
WGK Germany	3
Hazard Class	IRRITANT

42521-09-5 - Reference Information

use

methyl 2, 6-dichloro isonicotinate is an important pharmaceutical and chemical intermediate, which can be used to prepare 1H-pyrrole [3,2-b] pyridine compounds, and 1H-pyrrole [3,2-b] pyridine structure is the parent core structure for synthesizing a series of pharmacologically active drugs.

preparation

2, 6-dichloroisonicotinic acid (5g,26.04mmol) was suspended in anhydrous toluene (75ml). Sulfuryl chloride (19ml,260.4mmol) was added and the mixture was heated and refluxed for 4 hours. Excess sulfuryl chloride was removed and the solvent was removed by vacuum, anhydrous MeOH(25ml) was added and the reaction was continued stirring for 4 hours, the solvent was removed by vacuum to obtain a white solid, which was dried under vacuum (4.8g).

Last Update：2024-04-09 02:00:07