433695-36-4
N,N,2-trimethyl-5-nitrobenzenesulfonamide
CAS: 433695-36-4
Molecular Formula: C9H12N2O4S
433695-36-4 - Names and Identifiers
| Name | N,N,2-trimethyl-5-nitrobenzenesulfonamide |
| Synonyms | -50481 BRL 50481 N,N,2-trimethyl-5-nitrobenzenesulfonamide N,N,2-Trimethyl-5-nitrobenzenesulfonamide 5-NITRO-2,N,N-TRIMETHYLBENZENESULFONAMIDE N,N,2-trimethyl-5-nitro-benzenesulfonamide N,N,2-TRIMETHYL-5-NITRO-BENZENESULFONAMIDE Benzenesulfonamide, N,N,2-trimethyl-5-nitro- 3-(N,N-Dimethylsulfonamido)-4-methylnitrobenzene,5-Nitro-2-N,N-trimethylbenzenesulfonamide |
| CAS | 433695-36-4 |
| EINECS | 1592732-453-0 |
| InChI | InChI=1/C9H12N2O4S/c1-7-4-5-8(11(12)13)6-9(7)16(14,15)10(2)3/h4-6H,1-3H3 |
433695-36-4 - Physico-chemical Properties
| Molecular Formula | C9H12N2O4S |
| Molar Mass | 244.27 |
| Density | 1.334±0.06 g/cm3(Predicted) |
| Melting Point | 65-67°C |
| Boling Point | 391.1±52.0 °C(Predicted) |
| Flash Point | 190.4°C |
| Solubility | DMSO: 12mg/mL |
| Vapor Presure | 2.52E-06mmHg at 25°C |
| Appearance | solid |
| Color | white |
| pKa | -5?+-.0.70(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Refractive Index | 1.561 |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | BRL-50481 increases the cAMP content (19.1±6.2% of IBMX response at 300 μM) but is considerably less potent. BRL-50481 (30 μM) fails to suppress proliferation by itself but significantly potentiates the effect of rolipram. BRL-50481 (30 μM) has no effect on IL-15-induced proliferation but augments the inhibitory effect of rolipram. Pretreatment (30 min) of human monocytes with BRL-50481 has, by itself, a negligible (~2 to 10%) inhibitory effect on TNFα output at all concentrations tested. BRL-50481 also potentiates the inhibitory effect of PGE 2 on LPS-induced TNFα release. BRL-50481 has no significant effect by itself on κB-dependent transcription (5.6±1.9% inhibition at 30 μM) and fails to enhance the effect of rolipram (maximum inhibition, 52.9±2.7%; pIC 30 value of 5.33±0.12). BRL-50481 suppresses, in a concentration-dependent manner, LPS-induced TNFα release in monocytes in which PDE7A1 is induced (21.7±1.6% inhibition at 30 μM at the 12-h time point). |
433695-36-4 - Risk and Safety
| WGK Germany | 3 |
433695-36-4 - Introduction
N,N, is an organic compound with the chemical formula C9H10N4O4S. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: N,N, is a yellow crystal or crystalline powder.
-Melting point: About 163-166 degrees Celsius.
-Solubility: It can be dissolved in most organic solvents under acidic conditions, but it has poor solubility under alkaline conditions.
-Stability: Stable at room temperature, but may explode under the action of high temperature, open flame and strong oxidant.
Use:
-As a pesticide: N,N,N is often used as an insecticide and fungicide to control pests and pathogens on crops.
-Chemical intermediate: It can also be used as an intermediate in some organic synthesis and used to prepare other compounds.
Preparation Method:
N,N, can be synthesized by the following methods:
-Through nitration reaction: 2-methyl -1-naphthylamine is reacted with concentrated nitric acid in the presence of sulfuric acid, nitration gives 2-methyl-5-nitro-1-naphthylamine, which is then treated with sulfurous acid or ammonia to give the desired product.
Safety Information:
- N,N, is a toxic compound that can be harmful to humans on contact with skin, inhalation or ingestion.
-It should avoid storage or transportation with strong oxidants, strong alkalis and combustibles to prevent fire and explosion accidents.
-During use, wear personal protective equipment such as protective gloves, glasses and respirators, and ensure that you operate in a well-ventilated environment.
Nature:
-Appearance: N,N, is a yellow crystal or crystalline powder.
-Melting point: About 163-166 degrees Celsius.
-Solubility: It can be dissolved in most organic solvents under acidic conditions, but it has poor solubility under alkaline conditions.
-Stability: Stable at room temperature, but may explode under the action of high temperature, open flame and strong oxidant.
Use:
-As a pesticide: N,N,N is often used as an insecticide and fungicide to control pests and pathogens on crops.
-Chemical intermediate: It can also be used as an intermediate in some organic synthesis and used to prepare other compounds.
Preparation Method:
N,N, can be synthesized by the following methods:
-Through nitration reaction: 2-methyl -1-naphthylamine is reacted with concentrated nitric acid in the presence of sulfuric acid, nitration gives 2-methyl-5-nitro-1-naphthylamine, which is then treated with sulfurous acid or ammonia to give the desired product.
Safety Information:
- N,N, is a toxic compound that can be harmful to humans on contact with skin, inhalation or ingestion.
-It should avoid storage or transportation with strong oxidants, strong alkalis and combustibles to prevent fire and explosion accidents.
-During use, wear personal protective equipment such as protective gloves, glasses and respirators, and ensure that you operate in a well-ventilated environment.
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: 5-Nitro-2,N,N-Trimethylbenzenesulfonamide Visit Supplier Webpage Request for quotationCAS: 433695-36-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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