437-83-2
3-fluoro-O-anisidine
CAS: 437-83-2
Molecular Formula: C7H8FNO
437-83-2 - Names and Identifiers
| Name | 3-fluoro-O-anisidine |
| Synonyms | 3-fluoro-O-anisidine 3-Fluoro-2-methoxyan 3-Fluoro-2-Methoxyailine 3-Fluoro-2-methoxyaniline 3-FLUORO-2-METHOXYANILINE (S)-(+)-2-Methylpiperidine 3-FLUORO-2-METHOXYBENZENAMINE 3-Fluoro-2-Methoxy-Phenylamine 3-FLUORO-2-METHOXY-PHENYLAMINE 2-Amino-6-fluoroanisole, 3-Fluoro-o-anisidine |
| CAS | 437-83-2 |
| InChI | InChI=1/C7H8FNO/c1-10-7-5(8)3-2-4-6(7)9/h2-4H,9H2,1H3 |
437-83-2 - Physico-chemical Properties
| Molecular Formula | C7H8FNO |
| Molar Mass | 141.14 |
| Density | 0.823g/mLat 25°C(lit.) |
| Melting Point | 162 °C |
| Boling Point | 117-121°C(lit.) |
| Flash Point | 80°C |
| Vapor Presure | 0.129mmHg at 25°C |
| pKa | 3.52±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.446(lit.) |
| MDL | MFCD00007759 |
437-83-2 - Risk and Safety
| Risk Codes | R11 - Highly Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. R24/25 - |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | UN 1993 3/PG 1 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| Hazard Class | 3.2 |
| Packing Group | III |
437-83-2 - Introduction
3-fluoro-O-anisidine(3-fluoro-O-anisidine) is an organic compound whose chemical formula is C7H8FNO. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: 3-fluoro-O-anisidine is a colorless to pale yellow liquid.
-Melting point: 43-45 degrees Celsius
-Boiling point: 221-223 degrees Celsius
-Density: 1.18 g/ml
-Soluble: Soluble in ethanol and ether
Use:
- 3-fluoro-O-anisidine is widely used as an intermediate in the pharmaceutical industry, such as synthetic pharmaceutical ingredients.
-It can also be used in organic synthesis reactions, such as as reagents in fluorination reactions and aromatic substitution reactions.
Preparation Method:
The preparation method of-3-fluoro-O-anisidine can be obtained by fluorination reaction at the ortho-position of the methyl group, which can be carried out by using a fluorinating agent, such as boron trifluoride and hydrogen fluoride.
-Methoxyaniline and fluorinating agent need to maintain proper temperature and reaction time during the reaction.
Safety Information:
- 3-fluoro-O-anisidine is irritating and toxic, avoid contact with skin and eyes.
-When using, you need to operate in a well-ventilated place and wear appropriate protective equipment, such as gloves and protective glasses.
-Avoid inhaling its vapor or dust and avoid swallowing.
-The container should be closed for storage, away from fire and oxidant.
Nature:
-Appearance: 3-fluoro-O-anisidine is a colorless to pale yellow liquid.
-Melting point: 43-45 degrees Celsius
-Boiling point: 221-223 degrees Celsius
-Density: 1.18 g/ml
-Soluble: Soluble in ethanol and ether
Use:
- 3-fluoro-O-anisidine is widely used as an intermediate in the pharmaceutical industry, such as synthetic pharmaceutical ingredients.
-It can also be used in organic synthesis reactions, such as as reagents in fluorination reactions and aromatic substitution reactions.
Preparation Method:
The preparation method of-3-fluoro-O-anisidine can be obtained by fluorination reaction at the ortho-position of the methyl group, which can be carried out by using a fluorinating agent, such as boron trifluoride and hydrogen fluoride.
-Methoxyaniline and fluorinating agent need to maintain proper temperature and reaction time during the reaction.
Safety Information:
- 3-fluoro-O-anisidine is irritating and toxic, avoid contact with skin and eyes.
-When using, you need to operate in a well-ventilated place and wear appropriate protective equipment, such as gloves and protective glasses.
-Avoid inhaling its vapor or dust and avoid swallowing.
-The container should be closed for storage, away from fire and oxidant.
Last Update：2024-04-09 02:00:46
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