444120-91-6

444120-91-6 - Names and Identifiers

Name	6-Chloropyridine-3-boronic acid
Synonyms	2-Chloropyridine-5-b 2-chloro-5-pyridine acid 6-Chloro-3-pyridylboronic 2-choropyridine-5-boronic acid 2-Chloropyridine-5-boronic acid 6-Chloropyridine-3-boronic acid 2-CHLORO-5-PYRIDYL BORONIC ACID 2-Chloro-5-pyridineboronic acid 6-Chloropyridin-3-Ylboronic Acid (6-chloropyridin-3-yl)boronic acid 6-CHLOROPYRIDIN-3-YL-3-BORONIC ACID B-(6-Chloro-pyridin-3-yl)boronic acid Boronic acid, B-(6-chloro-3-pyridinyl)- 2-Chloropyridine-5-boronic Acid (contains varying amounts of Anhydride) 6-Chloropyridine-3-boronic acid (contains varying aMounts of Anhydride)
CAS	444120-91-6
EINECS	628-524-0
InChI	InChI=1/C5H5BClNO2/c7-5-2-1-4(3-8-5)6(9)10/h1-3,9-10H
InChIKey	WPAPNCXMYWRTTL-UHFFFAOYSA-N

444120-91-6 - Physico-chemical Properties

Molecular Formula	C5H5BClNO2
Molar Mass	157.36
Density	1.41±0.1 g/cm3(Predicted)
Melting Point	165°C(lit.)
Boling Point	336.9±52.0 °C(Predicted)
Flash Point	157.5°C
Vapor Presure	4.27E-05mmHg at 25°C
Appearance	Bright yellow crystalline powder
BRN	9119810
pKa	6.70±0.10(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.559
MDL	MFCD03094998

444120-91-6 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany	3
HS Code	29349990
Hazard Class	IRRITANT

444120-91-6 - Introduction

6-Chloropyridine-3-boronic acid is an organic compound with the chemical formula C5H4BClNO2. The following is a description of its nature, use, preparation and safety information:

Nature:
6-Chloropyridine-3-boronic acid is a white or light yellow crystal with a high melting point (about 183-185 degrees Celsius). It is stable at room temperature, but may decompose at high temperatures. It is slightly soluble in water and soluble in organic solvents such as ethanol, dimethyl ether, etc. Its chemical properties are relatively stable, and it is an important organic boron reagent.

Use:
6-Chloropyridine-3-boronic acid is an important intermediate in organic synthesis. It is often used to construct boron-containing compounds, such as for the synthesis of boron-containing compounds such as pyridine and benzothiophene, and is mainly used in the fields of drugs and materials. In addition, it is also widely used in metal-organic framework (MOF) materials and green catalysis.

Preparation Method:
6-Chloropyridine-3-boronic acid has many preparation methods, and the commonly used method is to react 6-chloropyridine with boric acid. Specifically, 6-chloropyridine can be reacted with triphenylboron or allyl borate under the catalysis of an oxidizing agent to obtain the product. The choice of reaction conditions and catalyst depends on the specific experimental requirements.

Safety Information:
6-Chloropyridine-3-boronic acid is irritating and may cause inflammation when in contact with skin and eyes. During use and preparation, care should be taken to avoid direct contact. Wear personal protective equipment, such as gloves, glasses and outside laboratory protective equipment. It should be operated in a well-ventilated place to avoid inhaling its vapors. When stored, it should be placed in a dry, cool, ventilated place, and stored in isolation from flammable and oxidizable substances. Disposal of waste shall be carried out in accordance with local regulations and hazardous waste disposal practices.

Last Update：2024-04-09 20:52:54