446-31-1
4-Amino-2-fluorobenzoic acid
CAS: 446-31-1
Molecular Formula: C7H6FNO2
446-31-1 - Names and Identifiers
| Name | 4-Amino-2-fluorobenzoic acid |
| Synonyms | BUTTPARK 22 9-96 4-AMINO-2-FLUOROBENZ 4-Carboxy-3-fluoroaniline 2-FLUORO-4-AMINOBENZOIC ACID 4-Amino-2-fluorobenzoic acid 4-AMINO-2-FLUOROBENZOIC ACID 4-azanyl-2-fluoro-benzoic acid Benzoic acid, 4-amino-2-fluoro- 4-AMINO-2-FLUOROBENZENECARBOXYLIC ACID |
| CAS | 446-31-1 |
| EINECS | 207-163-9 |
| InChI | InChI=1/C7H6FNO2/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3H,9H2,(H,10,11) |
| InChIKey | QHERSCUZBKDVOC-UHFFFAOYSA-N |
446-31-1 - Physico-chemical Properties
| Molecular Formula | C7H6FNO2 |
| Molar Mass | 155.13 |
| Density | 1.430±0.06 g/cm3(Predicted) |
| Melting Point | 210 °C (dec.) |
| Boling Point | 336.1±27.0 °C(Predicted) |
| Flash Point | 146.2°C |
| Vapor Presure | 0.000155mmHg at 25°C |
| pKa | 3.93±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.606 |
| MDL | MFCD01569397 |
| Physical and Chemical Properties | Melting Point: 216-217 |
446-31-1 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
446-31-1 - Reference Information
| use | 4-amino -2-fluorobenzoic acid is an important intermediate of many drugs and is widely used in the fields of organic synthesis and pharmaceutical industry. |
| preparation | at present, the process preparation methods of 4-amino -2-fluorobenzoic acid mainly include WO2001042198,WO2004011460,WO2007138033 and WO2010034796. it is WO2010132615 reported that 2-fluoro-4-nitrobenzoic acid is used as raw material and is prepared by Pd/C hydrogenation reduction, and its raw material 2-fluoro-4-nitrobenzoic acid is often prepared by oxidation of 2-fluoro-4-nitrotoluene and strong oxidizing potassium permanganate or potassium dichromate; in addition, there are WO2008118758,WO2010035166 reported The 2-fluoro-4-aminobenzonitrile is prepared by alkaline hydrolysis. |
Last Update：2024-04-09 19:05:03
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