446859-33-2
RepSox
CAS: 446859-33-2
Molecular Formula: C17H13N5
446859-33-2 - Names and Identifiers
446859-33-2 - Physico-chemical Properties
| Molecular Formula | C17H13N5 |
| Molar Mass | 287.32 |
| Density | 1.296±0.06 g/cm3(Predicted) |
| Melting Point | 195 °C |
| Boling Point | 501.9±50.0 °C(Predicted) |
| Solubility | DMSO: >20mg/mL |
| Appearance | Yellow solid |
| Color | Pale yellow |
| pKa | 10.05±0.50(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| MDL | MFCD09037561 |
| Use | RepSox |
| In vitro study | RepSox inhibits ATP binding to ALK5 and inhibits ALK5 autophosphorylation with IC50 of 23 nM and 4 nM, respectively. RepSox inhibited TGF-β-induced cell PAI-1 luciferase activity with an IC50 of 18 nM. RepSox can successfully displace Sox2 in reprogramming by inhibiting transforming growth factor-β (TGF-β) signaling, which in turn leads to Nanog expression. RepSox induced reprogramming does not require chromatin remodeling. RepSox is effective for generating iPSCs. |
| In vivo study | RepSox is injected into the blastocyst and helps to form a chimera embryo in the body. RepSox was treated for one day, enough to replace the transgenic Sox2. |
446859-33-2 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 |
| WGK Germany | 3 |
446859-33-2 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.48 ml | 17.402 ml | 34.804 ml |
| 5 mM | 0.696 ml | 3.48 ml | 6.961 ml |
| 10 mM | 0.348 ml | 1.74 ml | 3.48 ml |
| 5 mM | 0.07 ml | 0.348 ml | 0.696 ml |
Last Update：2024-01-02 23:10:35
446859-33-2 - Reference Information
| biological activity | RepSox (E-616452, SJN 2511, ALK5 Inhibitor II) is a potent, A selective TGFβR-1/ALK5 inhibitor that acts on ATP binding to ALK5 and ALK5 autophosphorylation with an IC50 of 23 nM and 4 nM, respectively, in a cell-free assay. |
| Target | Value |
| TGFβR1(ALK5) (Cell-free assay) | 4 nM |
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: RepSox Visit Supplier Webpage Request for quotationCAS: 446859-33-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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