452-80-2
2-Fluoro-4-methylaniline
CAS: 452-80-2
Molecular Formula: C7H8FN
452-80-2 - Names and Identifiers
452-80-2 - Physico-chemical Properties
| Molecular Formula | C7H8FN |
| Molar Mass | 125.14 |
| Density | 1.108 g/mL at 25 °C (lit.) |
| Melting Point | 3 °C |
| Boling Point | 70-71 °C/7 mmHg (lit.) |
| Flash Point | 175°F |
| Water Solubility | Not miscible in water. |
| Vapor Presure | 0.239mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear orange to orange-brown |
| BRN | 2637578 |
| pKa | 3?+-.0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | n20/D 1.533(lit.) |
| Physical and Chemical Properties | Light yellow liquid |
452-80-2 - Risk and Safety
| Risk Codes | R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2810 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | XU6650000 |
| HS Code | 29214300 |
| Hazard Note | Toxic/Irritant |
| Hazard Class | 6.1 |
| Packing Group | III |
452-80-2 - Introduction
2-Fluoro-4-methylaniline is an organic compound with the chemical formula C7H8FN. The following is a description of its nature, use, formulation and safety information:
Nature:
1. Appearance: 2-Fluoro-4-methylaniline is colorless to light yellow crystal or liquid.
2. Solubility: Soluble in most organic solvents, such as alcohols, ethers and ketones.
Use:
1. Chemical synthesis: It can be used to synthesize other compounds, such as heterocyclic compounds and organometallic compounds.
2. drug research: the compound can be used for the research of anticancer drugs and pharmaceutical intermediates.
Preparation Method:
2-Fluoro-4-methylaniline can be prepared by the following methods:
1. 4-methylaniline reacts with fluoride to generate 2-Fluoro-4-methylaniline.
2. The p-nitrotoluene is reacted with hydrofluoric acid and then reduced to give 2-Fluoro-4-methylaniline.
Safety Information:
1. 2-Fluoro-4-methylaniline may release toxic gases when heated or in contact with flames.
2. contact may cause eye and skin irritation, should take appropriate protective measures.
3. Avoid inhaling its vapor or solution during operation. Wear appropriate personal protective equipment such as respirators and chemical gloves when used.
4. During storage, 2-Fluoro-4-methylaniline should be kept in a sealed container, away from fire and oxidizing agents.
Please note that this is only a general introduction to 2-Fluoro-4-methylaniline. For specific applications and more detailed safety information, please refer to the relevant literature or consult a professional.
Nature:
1. Appearance: 2-Fluoro-4-methylaniline is colorless to light yellow crystal or liquid.
2. Solubility: Soluble in most organic solvents, such as alcohols, ethers and ketones.
Use:
1. Chemical synthesis: It can be used to synthesize other compounds, such as heterocyclic compounds and organometallic compounds.
2. drug research: the compound can be used for the research of anticancer drugs and pharmaceutical intermediates.
Preparation Method:
2-Fluoro-4-methylaniline can be prepared by the following methods:
1. 4-methylaniline reacts with fluoride to generate 2-Fluoro-4-methylaniline.
2. The p-nitrotoluene is reacted with hydrofluoric acid and then reduced to give 2-Fluoro-4-methylaniline.
Safety Information:
1. 2-Fluoro-4-methylaniline may release toxic gases when heated or in contact with flames.
2. contact may cause eye and skin irritation, should take appropriate protective measures.
3. Avoid inhaling its vapor or solution during operation. Wear appropriate personal protective equipment such as respirators and chemical gloves when used.
4. During storage, 2-Fluoro-4-methylaniline should be kept in a sealed container, away from fire and oxidizing agents.
Please note that this is only a general introduction to 2-Fluoro-4-methylaniline. For specific applications and more detailed safety information, please refer to the relevant literature or consult a professional.
Last Update：2024-04-09 15:17:57
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View History
452-80-2
2-(2-{[1-(3-chlorophenyl)propyl]amino}ethoxy)ethan-1-ol
(2-Oxo-2H-pyridin-1-yl)acetic acid
Butyric acid, 4-chloro-
3-(Benzyloxy)-4H-pyran-4-one
BENZENEETHANAMINE, 4-(DIFLUOROMETHYL)-
2-(2-{[1-(3-chlorophenyl)propyl]amino}ethoxy)ethan-1-ol
(2-Oxo-2H-pyridin-1-yl)acetic acid
Butyric acid, 4-chloro-
3-(Benzyloxy)-4H-pyran-4-one
BENZENEETHANAMINE, 4-(DIFLUOROMETHYL)-