452972-12-2

452972-12-2 - Names and Identifiers

Name	2-bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Synonyms	2-BROMOPYRIDINE-3-BORONIC ACID PINACOL ESTER 2-BROMO-3-PYRIDINEBORONIC ACID PINACOL ESTER 2-Bromopyridin-3-ylboronic acid pinacol ester 2-bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 2-BroMo-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine2 2-BROMO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE 2-(2-Bromo-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane2-Bromo-3-pyridylboronic Acid Pinacol Ester
CAS	452972-12-2
EINECS	279-594-0
InChI	InChI=1/C11H15BBrNO2/c1-10(2)11(3,4)16-12(15-10)8-6-5-7-14-9(8)13/h5-7H,1-4H3

452972-12-2 - Physico-chemical Properties

Molecular Formula	C11H15BBrNO2
Molar Mass	283.96
Density	1.329g/mLat 25°C(lit.)
Melting Point	28 °C
Boling Point	353.9±27.0 °C(Predicted)
Flash Point	>230°F
Solubility	soluble in Toluene
Vapor Presure	7.08E-05mmHg at 25°C
Appearance	powder to lump
Color	White to Almost white
pKa	0.78±0.12(Predicted)
Storage Condition	Room Temprature
Refractive Index	1.527

452972-12-2 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
Hazard Class	IRRITANT

452972-12-2 - Introduction

2-bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is an organic compound with the chemical formula C12H15BBrNO2. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: Colorless or light yellow solid.
-Melting point: about 120-125°C.
-Solubility: Soluble in common organic solvents such as dimethyl sulfoxide (DMSO), dichloromethane and ethanol.
-Stability: relatively stable under normal storage and handling conditions.

Use:
-Chemical reagent: 2-bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine can be used as a reagent in organic synthesis to construct compounds containing pyridine ring and boronic acid pinacol group.
-Catalyst: It can also be used as a substrate or intermediate in the catalyst to participate in various organic synthesis reactions.

Preparation Method:
2-bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine can be synthesized by the following steps:
1. Add 2-bromopyridine and 4,4,5,5-tetramethyl -1,3, 2-dithiadioxy -2-cyclobutane into the reaction flask;
2. Add sodium hydroxide (NaOH) solution and stir the reactant suspension;
3. drop tris (diethylborane) into the suspension and maintain the reaction temperature;
4. After completion of the reaction, the reaction solution was diluted with water, and then the product was extracted with an organic solvent.

Safety Information:
Specific safety information for the 2-bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine can be obtained from the relevant safety data sheet. When handling and using the compound, follow appropriate laboratory safety practices, such as wearing protective gloves and goggles, and ensure good ventilation.

Last Update：2024-04-10 22:29:15