453557-78-3
2-Chloro-5-(1H-pyrazol-1-ylmethyl)-1,3-thiazole
CAS: 453557-78-3
Molecular Formula: C7H6ClN3S
453557-78-3 - Names and Identifiers
453557-78-3 - Physico-chemical Properties
| Molecular Formula | C7H6ClN3S |
| Molar Mass | 199.66 |
| Density | 1.51±0.1 g/cm3(Predicted) |
| Melting Point | 50-52°C |
| Boling Point | 376.9±44.0 °C(Predicted) |
| pKa | 1.68±0.10(Predicted) |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD01871711 |
453557-78-3 - Risk and Safety
| Hazard Class | IRRITANT |
453557-78-3 - Introduction
Nature:
-Appearance: Colorless or light yellow solid
-melting point: 72-74 ℃
-Boiling point: 318.3 ℃
-Density: 1.434g/cm³
-Solubility: Soluble in ethanol and ether, slightly soluble in water
Use:
2-Chloro-5-(1H-pyrazol-1-ylmethyl)-1,3-thiazole has certain applications in drug research and pesticide development. It is a heterocyclic compound with some biological activity, so it is widely used in the process of synthesizing molecules and compounds with biological activity.
Preparation Method:
The synthetic method of 2-Chloro-5-(1H-pyrazol-1-ylmethyl)-1,3-thiazole generally includes the following steps:
1. First, 1,3-dichloroisocyanate is reacted with thiourea in the presence of 1H-pyrazole methanol and HCl to produce 2-amino-5-chloro-1, 3-thiazole.
2. Then, 2-amino -5-chloro-1, 3-thiazole was reacted with CHOH under alkaline conditions to synthesize 2-amino -5-(1H-pyrazol-1-yl)-1,3-thiazole.
3. Finally, 2-amino -5-(1H-pyrazol-1-yl)-1,3-thiazole was chlorinated using acetone in the presence of ammonium chloride to produce 2-Chloro-5-(1H-pyrazol-1-ylmethyl)-1,3-thiazole.
Safety Information:
The specific safety information of -2-Chloro-5-(1H-pyrazol-1-ylmethyl)-1,3-thiazole has not been publicly reported at present, so it should be treated with caution.
-When handling the compound, wear appropriate protective gloves, protective glasses and protective face mask to ensure good ventilation.
-Avoid inhalation, ingestion or contact with skin. Do not smoke, eat or drink during operation.
-Observe safety regulations and consult a professional when using or disposing of chemicals.
Last Update：2024-04-09 21:01:54
