453590-24-4
TIE-2/VEGFR-2 kinase-IN-1
CAS: 453590-24-4
Molecular Formula: C13H11N3O2
453590-24-4 - Names and Identifiers
| Name | TIE-2/VEGFR-2 kinase-IN-1 |
| Synonyms | Kinase IN-1 6-(4-METHOXYPHENYL)FURO[2,3-D]PYRIMIDIN-4-AMINE 6-(4-methoxy-phenyl)-furo[2,3-d]pyrimidin-4-ylamine |
| CAS | 453590-24-4 |
453590-24-4 - Physico-chemical Properties
| Molecular Formula | C13H11N3O2 |
| Molar Mass | 241.25 |
| Storage Condition | -20°C，密封，干燥 |
| In vitro study | Angiopoieten 1 is a ligand for the endotheiium-specific receptor tyrosine kinase, TIE-2 is a novel angiogenic factor.Inhibition of TIE-2 is expected to serve to disrupt remodeling and maturation of new vasculature initiated by angiogenesis thereby disrupting the angiogenic process. Inhibition at the kinase domain binding site of VEGFR-2 would block phosphorylation of tyrosine residues and serve to disrupt initiation of angiogenesis. |
