454487-07-1
L-Cysteine, L-cysteinylglycyl-L-asparaginyl-L-lysyl-L-arginyl-L-threonyl-L-arginylglycyl-, cyclic (1→9)-disulfide
CAS: 454487-07-1
Molecular Formula: C36H65N17O12S2
454487-07-1 - Names and Identifiers
454487-07-1 - Physico-chemical Properties
| Molecular Formula | C36H65N17O12S2 |
| Molar Mass | 992.14 |
| In vivo study | LyP-1 (8 weeks) shows a remarkable reduction in plaque formation and plaque occupation rates in the LyP-1-treated group. In addition, a higher apoptotic rate in macrophages released from hypoxic plaques is observed after the treatment of LyP-1when compared to control peptide.The LyP-1 peptide is labeled with a near-infrared fluorophore (Cy5.5) for optical imaging.At days 3, 7, 14 and 21 after inoculation with 4T1 cells, tumor-bearing BALB/C mice is injected Cy5.5-LyP-1 (0.8 nmol) through the middle phalanges of the upper extremities of the tumor-bearing mice. The fluorescence intensities were 0.024, 0.038, 0.048 and 0.106×10 6 photon/cm 2 /sec respectively at days 3, 7, 14 and 21 after tumor cell inoculation, which are 1.02, 1.63, 2.04, and 4.52-fold higher than in the contralateral LNs. Cy5.5-LyP-1 staining in LNs co-localized with LYVE-1, suggesting lymphatics-specific binding of LyP-1 peptide. |
454487-07-1 - Reference Information
| biological activity | LyP-1 is a cyclic 9 amino acid tumor localization peptide, selectively binds to its p32 receptor protein. |
| in vivo study | LyP-1 (8 μweeks) shows a remarked reduction in the LyP-1-treated group. In addition, a higher tolerant rate in macrophages released from hyposic plaques is observed after the treatment of LyP-1when compared to control peptide.The LyP-1 peptide is Labelled with a near-infra fluorophore (Cy5.5) for optical imaging.At days 3, 7, 14 and 21 after inoculation with 4T1 cells, tumor-bearing BALB/C mice is injected Cy5.5-LyP-1 (0.8 nmol) through the middle phalanges of the upper extremities of the tumor-bearing mice. The fluorescence intensities were 0.024, 0.038, 0.048 and 0.106×10 6 photon/cm 2 /sec respectively at days 3 7, 14 and 21 after tumor cell inoculation, which are 1.02, 1.63, 2.04, and 4.52-fold higher than in the contralateral LNs. Cy5.5-LyP-1 staining in LNs co-localized with LYVE-1, suggesting lymphatics-specific binding of LyP-1 peptide. |
Last Update：2024-04-09 22:09:11
